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Eversion endarterectomy under full prasugrel treatment
The third-generation thienopyridine prasugrel has much stronger antiplatelet effect compared to other current antiplatelet inhibitors and exhibits practically zero resistance in healthy people. Prasugrel is used as a pre- and post-treatment in percutaneous coronary or neurovascular interventions wit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692133/ https://www.ncbi.nlm.nih.gov/pubmed/29163956 http://dx.doi.org/10.1177/2050313X17741826 |
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author | Kotsis, Thomas Christoforou, Panagitsa Asaloumidis, Nikolaos Argyra, Erifyli |
author_facet | Kotsis, Thomas Christoforou, Panagitsa Asaloumidis, Nikolaos Argyra, Erifyli |
author_sort | Kotsis, Thomas |
collection | PubMed |
description | The third-generation thienopyridine prasugrel has much stronger antiplatelet effect compared to other current antiplatelet inhibitors and exhibits practically zero resistance in healthy people. Prasugrel is used as a pre- and post-treatment in percutaneous coronary or neurovascular interventions with parallel aspirin regime. However, as there is a higher reported bleeding with intraluminal interventions and meticulous technique is recommended, there is nearly non-existent international experience of open surgery under full prasugrel treatment. We present, herein, a case of open carotid endarterectomy with the eversion technique in an asymptomatic patient with carotid stenosis, who was receiving dual antiplatelet therapy with aspirin and prasugrel, due to a previous insertion of two newer drug-eluting stents at the left anterior descending artery and the right coronary artery. The resistance test to prasugrel showed complete inhibition of platelet function. Open surgery was performed under continuation of prasugrel treatment and interruption of aspirin for 3 days before surgery. No perioperative and postoperative neurologic or cardiologic event occurred. No bleeding at the cervical or cerebral area was noted. |
format | Online Article Text |
id | pubmed-5692133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-56921332017-11-21 Eversion endarterectomy under full prasugrel treatment Kotsis, Thomas Christoforou, Panagitsa Asaloumidis, Nikolaos Argyra, Erifyli SAGE Open Med Case Rep Case Report The third-generation thienopyridine prasugrel has much stronger antiplatelet effect compared to other current antiplatelet inhibitors and exhibits practically zero resistance in healthy people. Prasugrel is used as a pre- and post-treatment in percutaneous coronary or neurovascular interventions with parallel aspirin regime. However, as there is a higher reported bleeding with intraluminal interventions and meticulous technique is recommended, there is nearly non-existent international experience of open surgery under full prasugrel treatment. We present, herein, a case of open carotid endarterectomy with the eversion technique in an asymptomatic patient with carotid stenosis, who was receiving dual antiplatelet therapy with aspirin and prasugrel, due to a previous insertion of two newer drug-eluting stents at the left anterior descending artery and the right coronary artery. The resistance test to prasugrel showed complete inhibition of platelet function. Open surgery was performed under continuation of prasugrel treatment and interruption of aspirin for 3 days before surgery. No perioperative and postoperative neurologic or cardiologic event occurred. No bleeding at the cervical or cerebral area was noted. SAGE Publications 2017-11-14 /pmc/articles/PMC5692133/ /pubmed/29163956 http://dx.doi.org/10.1177/2050313X17741826 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Kotsis, Thomas Christoforou, Panagitsa Asaloumidis, Nikolaos Argyra, Erifyli Eversion endarterectomy under full prasugrel treatment |
title | Eversion endarterectomy under full prasugrel treatment |
title_full | Eversion endarterectomy under full prasugrel treatment |
title_fullStr | Eversion endarterectomy under full prasugrel treatment |
title_full_unstemmed | Eversion endarterectomy under full prasugrel treatment |
title_short | Eversion endarterectomy under full prasugrel treatment |
title_sort | eversion endarterectomy under full prasugrel treatment |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692133/ https://www.ncbi.nlm.nih.gov/pubmed/29163956 http://dx.doi.org/10.1177/2050313X17741826 |
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