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Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study

BACKGROUND: Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. There is evidence that vitamin D deficiency can be associated with infectious diseases. The aim of this study was to compare the levels of vitamin D between patients with CAP and healthy cont...

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Autores principales: Mamani, Mojgan, Muceli, Neda, Ghasemi Basir, Hamid Reza, Vasheghani, Maryam, Poorolajal, Jalal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692194/
https://www.ncbi.nlm.nih.gov/pubmed/29180888
http://dx.doi.org/10.2147/IJGM.S149049
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author Mamani, Mojgan
Muceli, Neda
Ghasemi Basir, Hamid Reza
Vasheghani, Maryam
Poorolajal, Jalal
author_facet Mamani, Mojgan
Muceli, Neda
Ghasemi Basir, Hamid Reza
Vasheghani, Maryam
Poorolajal, Jalal
author_sort Mamani, Mojgan
collection PubMed
description BACKGROUND: Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. There is evidence that vitamin D deficiency can be associated with infectious diseases. The aim of this study was to compare the levels of vitamin D between patients with CAP and healthy controls. METHODS: In a case-control study on 73 patients with CAP and 76 healthy controls, the serum concentration of 25-hydroxyvitamin D (25[OH]D) was measured. Severity and outcomes of disease and also duration of hospital stay were compared in patients with different levels of 25(OH)D. The severity of CAP was assessed using the CURB-65 score (confusion, uremia, respiratory rate, low blood pressure, age ≥65 years) and was also reflected by the length of hospital stay, admission to intensive care unit (ICU), and 30-day mortality. RESULTS: In total, 81.2% of the study population had vitamin D levels <30 ng/dL. The risk of pneumonia among subjects with deficient vitamin D levels was 3.69 (95% CI: 1.46, 9.31) times of those with sufficient vitamin D level (P=0.006). Prevalence of severe deficiency of vitamin D in scores three and four of CURB-65 (59.38%), was far more than scores one and two (31.71%). Also, results indicated patients with severe deficiency had a higher risk for ICU admission, 30-day mortality, and longer hospitalization stay, but these were not statistically significant. CONCLUSION: According to findings, a low level of 25(OH)D is associated with a higher incidence of CAP and more severe disease. It is recommended to pay more attention to vitamin D deficiency in infectious diseases, particularly in CAP patients.
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spelling pubmed-56921942017-11-27 Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study Mamani, Mojgan Muceli, Neda Ghasemi Basir, Hamid Reza Vasheghani, Maryam Poorolajal, Jalal Int J Gen Med Original Research BACKGROUND: Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. There is evidence that vitamin D deficiency can be associated with infectious diseases. The aim of this study was to compare the levels of vitamin D between patients with CAP and healthy controls. METHODS: In a case-control study on 73 patients with CAP and 76 healthy controls, the serum concentration of 25-hydroxyvitamin D (25[OH]D) was measured. Severity and outcomes of disease and also duration of hospital stay were compared in patients with different levels of 25(OH)D. The severity of CAP was assessed using the CURB-65 score (confusion, uremia, respiratory rate, low blood pressure, age ≥65 years) and was also reflected by the length of hospital stay, admission to intensive care unit (ICU), and 30-day mortality. RESULTS: In total, 81.2% of the study population had vitamin D levels <30 ng/dL. The risk of pneumonia among subjects with deficient vitamin D levels was 3.69 (95% CI: 1.46, 9.31) times of those with sufficient vitamin D level (P=0.006). Prevalence of severe deficiency of vitamin D in scores three and four of CURB-65 (59.38%), was far more than scores one and two (31.71%). Also, results indicated patients with severe deficiency had a higher risk for ICU admission, 30-day mortality, and longer hospitalization stay, but these were not statistically significant. CONCLUSION: According to findings, a low level of 25(OH)D is associated with a higher incidence of CAP and more severe disease. It is recommended to pay more attention to vitamin D deficiency in infectious diseases, particularly in CAP patients. Dove Medical Press 2017-11-13 /pmc/articles/PMC5692194/ /pubmed/29180888 http://dx.doi.org/10.2147/IJGM.S149049 Text en © 2017 Mamani et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Mamani, Mojgan
Muceli, Neda
Ghasemi Basir, Hamid Reza
Vasheghani, Maryam
Poorolajal, Jalal
Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
title Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
title_full Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
title_fullStr Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
title_full_unstemmed Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
title_short Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
title_sort association between serum concentration of 25-hydroxyvitamin d and community-acquired pneumonia: a case-control study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692194/
https://www.ncbi.nlm.nih.gov/pubmed/29180888
http://dx.doi.org/10.2147/IJGM.S149049
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