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PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability through the activation of voltage-gated KCNQ2–5 potassium channels. Retigabine binds to the pore-forming domain, causing a hyperpolarizing shift in the voltage dependence of channel activation. To elucidate...

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Detalles Bibliográficos
Autores principales:	Kim, Robin Y., Pless, Stephan A., Kurata, Harley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692535/ https://www.ncbi.nlm.nih.gov/pubmed/29078287 http://dx.doi.org/10.1073/pnas.1705802114

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