Cargando…

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease

Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by pathology of accumulated amyloid β (Aβ) and phosphorylated tau proteins in the brain. Postmortem degradation and cellular complexity within the brain have limited approaches to molecularly define the causal relationship...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mano, Tatsuo, Nagata, Kenichi, Nonaka, Takashi, Tarutani, Airi, Imamura, Tomohiro, Hashimoto, Tadafumi, Bannai, Taro, Koshi-Mano, Kagari, Tsuchida, Takeyuki, Ohtomo, Ryo, Takahashi-Fujigasaki, Junko, Yamashita, Satoshi, Ohyagi, Yasumasa, Yamasaki, Ryo, Tsuji, Shoji, Tamaoka, Akira, Ikeuchi, Takeshi, Saido, Takaomi C., Iwatsubo, Takeshi, Ushijima, Toshikazu, Murayama, Shigeo, Hasegawa, Masato, Iwata, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692545/ https://www.ncbi.nlm.nih.gov/pubmed/29042514 http://dx.doi.org/10.1073/pnas.1707151114

Ejemplares similares

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight
por: Bannai, Taro, et al.
Publicado: (2019)

Neuron-specific analysis of histone modifications with post-mortem brains
por: Koshi-Mano, Kagari, et al.
Publicado: (2020)

Similarity between soybean and Arabidopsis seed methylomes and loss of non-CG methylation does not affect seed development
por: Lin, Jer-Young, et al.
Publicado: (2017)

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
por: Eguchi, Tomoya, et al.
Publicado: (2018)

Retinal microglia initiate neuroinflammation in ocular autoimmunity
por: Okunuki, Yoko, et al.
Publicado: (2019)

Automated Evaluation of Conventional Clock-Drawing Test Using Deep Neural Network: Potential as a Mass Screening Tool to Detect Individuals With Cognitive Decline
por: Sato, Kenichiro, et al.
Publicado: (2022)

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
por: Kaneshiro, Nanaka, et al.
Publicado: (2022)

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice
por: Kidana, Kiwami, et al.
Publicado: (2018)

Attempt to Predict A/T/N-Based Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Using a Peripheral Blood DNA Methylation Clock
por: Sato, Kenichiro, et al.
Publicado: (2020)

Facial nerve palsy following the administration of COVID-19 mRNA vaccines: analysis of a self-reporting database
por: Sato, Kenichiro, et al.
Publicado: (2021)

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
por: Wakabayashi, Tomoko, et al.
Publicado: (2019)

The olfactory basis of orchid pollination by mosquitoes
por: Lahondère, Chloé, et al.
Publicado: (2020)

Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils
por: Eto, Miki, et al.
Publicado: (2019)

Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis
por: Sato, Kenichiro, et al.
Publicado: (2019)

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities
por: Terakawa, Jumpei, et al.
Publicado: (2019)

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury
por: Miyauchi, Tomoyuki, et al.
Publicado: (2019)

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
por: Taniguchi-Watanabe, Sayuri, et al.
Publicado: (2015)

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment
por: Okunuki, Yoko, et al.
Publicado: (2018)

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants
por: Kunduri, Govind, et al.
Publicado: (2018)

DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer
por: Matsunuma, Ryoichi, et al.
Publicado: (2018)

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis
por: Kodama, Takahiro, et al.
Publicado: (2018)

Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration
por: Kishino, Yuya, et al.
Publicado: (2022)

Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort
por: Ihara, Ryoko, et al.
Publicado: (2018)

Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model
por: Ikeuchi, Hiroshi, et al.
Publicado: (2022)

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling
por: Mori, Akio, et al.
Publicado: (2019)

Local and global crosstalk among heterochromatin marks drives DNA methylome patterning in Arabidopsis
por: To, Taiko Kim, et al.
Publicado: (2022)

A novel frameshift GRN mutation results in frontotemporal lobar degeneration with a distinct clinical phenotype in two siblings: case report and literature review
por: Hosaka, Takashi, et al.
Publicado: (2017)

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
por: Ohtomo, Gaku, et al.
Publicado: (2017)

Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering
por: Suzuki, Yuta, et al.
Publicado: (2019)

Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1(+)CXCR5(−/dim) B-helper T cell induction
por: Eri, Toshiki, et al.
Publicado: (2017)

Extensive aggregation of α-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site
por: Riku, Yuichi, et al.
Publicado: (2013)

Isolated Abducens Nerve Palsy Caused by Anterior Inferior Cerebellar Artery Compression
por: Hara, Ryo, et al.
Publicado: (2022)

Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App(NL-G-F/NL-G-F) mice
por: Niikura, Ryo, et al.
Publicado: (2022)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration
por: Ishida, Kazuhisa, et al.
Publicado: (2022)

Double-Sided Nonalloyed Ohmic Contacts to Si-doped GaAs for Plasmoelectronic Devices
por: Mano, Takaaki, et al.
Publicado: (2019)

Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
por: Ito, Shingo, et al.
Publicado: (2023)

Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease
por: Suzuki, Kazushi, et al.
Publicado: (2020)

Molecular Pathogenesis and Disease-modifying Therapies of Alzheimer’s Disease and Related Disorders
por: Iwatsubo, Takeshi
Publicado: (2022)

Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies
por: Park, Sangeun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_473lc1ul5tsub5ei3nf3og1l53