Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model

During replication initiation, the core component of the helicase—the Mcm2-7 hexamer—is loaded on origin DNA as a double hexamer (DH). The two ring-shaped hexamers are staggered, leading to a kinked axial channel. How the origin DNA interacts with the axial channel is not understood, but the interac...

Descripción completa

Detalles Bibliográficos
Autores principales: Noguchi, Yasunori, Yuan, Zuanning, Bai, Lin, Schneider, Sarah, Zhao, Gongpu, Stillman, Bruce, Speck, Christian, Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692578/
https://www.ncbi.nlm.nih.gov/pubmed/29078375
http://dx.doi.org/10.1073/pnas.1712537114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692578/
https://www.ncbi.nlm.nih.gov/pubmed/29078375
http://dx.doi.org/10.1073/pnas.1712537114

Ejemplares similares