Role of Epinephrine and Extracorporeal Membrane Oxygenation in the Management of Ischemic Refractory Ventricular Fibrillation: A Randomized Trial in Pigs

Extracorporeal membrane oxygenation (ECMO) is used in cardiopulmonary resuscitation (CPR) of refractory cardiac arrest. The authors used a 2 × 2 study design to compare ECMO versus CPR and epinephrine versus placebo in a porcine model of ischemic refractory ventricular fibrillation (VF). Pigs underw...

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Detalles Bibliográficos
Autores principales: Bartos, Jason A., Voicu, Sebastian, Matsuura, Timothy R., Tsangaris, Adamantios, Sideris, Georgios, Oestreich, Brett A., George, Stephen A., Olson, Matthew, Shekar, Kadambari Chandra, Rees, Jennifer N., Carlson, Kathleen, Sebastian, Pierre, McKnite, Scott, Raveendran, Ganesh, Aufderheide, Tom P., Yannopoulos, Demetris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693223/
https://www.ncbi.nlm.nih.gov/pubmed/29152600
http://dx.doi.org/10.1016/j.jacbts.2017.02.003
Descripción
Sumario:Extracorporeal membrane oxygenation (ECMO) is used in cardiopulmonary resuscitation (CPR) of refractory cardiac arrest. The authors used a 2 × 2 study design to compare ECMO versus CPR and epinephrine versus placebo in a porcine model of ischemic refractory ventricular fibrillation (VF). Pigs underwent 5 min of untreated VF and 10 min of CPR, and were randomized to receive epinephrine versus placebo for another 35 min. Animals were further randomized to left anterior descending artery (LAD) reperfusion at minute 45 with ongoing CPR versus venoarterial ECMO cannulation at minute 45 of CPR and subsequent LAD reperfusion. Four-hour survival was improved with ECMO whereas epinephrine showed no effect.

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