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Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis

Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is frequently found in colorectal cancer. Loss of APC function results in deregulation of the Wnt/β-catenin signaling pathway causing overexpression of the c-MYC oncogene. In lymphoma, both p19ARF and ribosomal proteins RPL11 and...

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Detalles Bibliográficos
Autores principales:	Liu, Shijie, Tackmann, Nicole R., Yang, Jing, Zhang, Yanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693310/ https://www.ncbi.nlm.nih.gov/pubmed/27617574 http://dx.doi.org/10.1038/onc.2016.301

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