The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells

BACKGROUND: Proper repair and restart of stressed replication forks requires intact homologous recombination (HR). HR at stressed replication forks can be initiated by the 5′ endonuclease EEPD1, which cleaves the stalled replication fork. Inherited or acquired defects in HR, such as mutations in bre...

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Detalles Bibliográficos
Autores principales: Hromas, Robert, Kim, Hyun-Suk, Sidhu, Gurjit, Williamson, Elizabeth, Jaiswal, Aruna, Totterdale, Taylor A., Nole, Jocelyn, Lee, Suk-Hee, Nickoloff, Jac A., Kong, Kimi Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693420/
https://www.ncbi.nlm.nih.gov/pubmed/29145865
http://dx.doi.org/10.1186/s13058-017-0912-8

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