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Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whethe...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693436/ https://www.ncbi.nlm.nih.gov/pubmed/29149191 http://dx.doi.org/10.1371/journal.pone.0188122 |
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author | Mitra, Anish Snyder, Abraham Z. Tagliazucchi, Enzo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, Alan Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus |
author_facet | Mitra, Anish Snyder, Abraham Z. Tagliazucchi, Enzo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, Alan Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus |
author_sort | Mitra, Anish |
collection | PubMed |
description | Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. |
format | Online Article Text |
id | pubmed-5693436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56934362017-11-30 Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness Mitra, Anish Snyder, Abraham Z. Tagliazucchi, Enzo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, Alan Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus PLoS One Research Article Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. Public Library of Science 2017-11-17 /pmc/articles/PMC5693436/ /pubmed/29149191 http://dx.doi.org/10.1371/journal.pone.0188122 Text en © 2017 Mitra et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mitra, Anish Snyder, Abraham Z. Tagliazucchi, Enzo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, Alan Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
title | Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
title_full | Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
title_fullStr | Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
title_full_unstemmed | Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
title_short | Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
title_sort | resting-state fmri in sleeping infants more closely resembles adult sleep than adult wakefulness |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693436/ https://www.ncbi.nlm.nih.gov/pubmed/29149191 http://dx.doi.org/10.1371/journal.pone.0188122 |
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