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Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children

OBJECTIVE: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. METHODS: Community sample of 170 (92 boys and 78 girls) children aged 8–11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-e...

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Autores principales: Dencker, Magnus, Tanha, Tina, Karlsson, Magnus K., Wollmer, Per, Andersen, Lars B., Thorsson, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693439/
https://www.ncbi.nlm.nih.gov/pubmed/29149174
http://dx.doi.org/10.1371/journal.pone.0187494
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author Dencker, Magnus
Tanha, Tina
Karlsson, Magnus K.
Wollmer, Per
Andersen, Lars B.
Thorsson, Ola
author_facet Dencker, Magnus
Tanha, Tina
Karlsson, Magnus K.
Wollmer, Per
Andersen, Lars B.
Thorsson, Ola
author_sort Dencker, Magnus
collection PubMed
description OBJECTIVE: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. METHODS: Community sample of 170 (92 boys and 78 girls) children aged 8–11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO(2PEAK)), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D. RESULTS: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF, VO(2PEAK) and PP were; r = 0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P = 0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years. CONCLUSION: Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D.
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spelling pubmed-56934392017-11-30 Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children Dencker, Magnus Tanha, Tina Karlsson, Magnus K. Wollmer, Per Andersen, Lars B. Thorsson, Ola PLoS One Research Article OBJECTIVE: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. METHODS: Community sample of 170 (92 boys and 78 girls) children aged 8–11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO(2PEAK)), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D. RESULTS: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF, VO(2PEAK) and PP were; r = 0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P = 0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years. CONCLUSION: Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D. Public Library of Science 2017-11-17 /pmc/articles/PMC5693439/ /pubmed/29149174 http://dx.doi.org/10.1371/journal.pone.0187494 Text en © 2017 Dencker et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dencker, Magnus
Tanha, Tina
Karlsson, Magnus K.
Wollmer, Per
Andersen, Lars B.
Thorsson, Ola
Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
title Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
title_full Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
title_fullStr Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
title_full_unstemmed Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
title_short Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
title_sort cystatin b, cathepsin l and d related to surrogate markers for cardiovascular disease in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693439/
https://www.ncbi.nlm.nih.gov/pubmed/29149174
http://dx.doi.org/10.1371/journal.pone.0187494
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