Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

BACKGROUND: Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations are thought to be a rare cause of neuronal ceroid lipofuscinosis (NCL). Aged progranulin-knoc...

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Detalles Bibliográficos
Autores principales: Petkau, Terri L., Kosior, Natalia, de Asis, Kathleen, Connolly, Colúm, Leavitt, Blair R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693502/
https://www.ncbi.nlm.nih.gov/pubmed/29149899
http://dx.doi.org/10.1186/s12974-017-1000-9

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