Jak3 deficiency blocks innate lymphoid cell development

Loss-of-function mutations in the tyrosine kinase JAK3 cause autosomal recessive (AR) severe combined immunodeficiency (SCID). Defects in this form of SCID are restricted to the immune system, which led to the development of the immunosuppressive JAK inhibitors. We find that the B6.Cg-Nr1d1(tm1Ven)/...

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Detalles Bibliográficos
Autores principales: Robinette, Michelle L., Cella, Marina, Telliez, Jean Baptiste, Ulland, Tyler K., Barrow, Alexander D., Capuder, Kelly, Gilfillan, Susan, Lin, Lih-Ling, Notarangelo, Luigi D., Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693788/
https://www.ncbi.nlm.nih.gov/pubmed/28513593
http://dx.doi.org/10.1038/mi.2017.38

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