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Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study

BACKGROUND: The aim of this study was to determine whether saliva interleukin-6 (IL-6) levels are elevated in patients with rheumatoid arthritis versus a control group and examine the possible relationship between the oral condition and the risk of RA. MATERIAL AND METHODS: In 30 patients with RA an...

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Autores principales: Silvestre-Rangil, Javier, Bagán, Leticia, Silvestre, Francisco-Javier, Martinez-Herrera, Mayte, Bagán, José-Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694182/
https://www.ncbi.nlm.nih.gov/pubmed/28809379
http://dx.doi.org/10.4317/medoral.21937
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author Silvestre-Rangil, Javier
Bagán, Leticia
Silvestre, Francisco-Javier
Martinez-Herrera, Mayte
Bagán, José-Vicente
author_facet Silvestre-Rangil, Javier
Bagán, Leticia
Silvestre, Francisco-Javier
Martinez-Herrera, Mayte
Bagán, José-Vicente
author_sort Silvestre-Rangil, Javier
collection PubMed
description BACKGROUND: The aim of this study was to determine whether saliva interleukin-6 (IL-6) levels are elevated in patients with rheumatoid arthritis versus a control group and examine the possible relationship between the oral condition and the risk of RA. MATERIAL AND METHODS: In 30 patients with RA and 30 healthy controls, different periodontal indices were recorded; sialometric measurements were taken to determine resting whole saliva, stimulated whole saliva and stimulated parotid saliva flow; and the saliva IL-6 levels were measured. Logistic regression analysis was performed, with the presence or absence of RA as dependent variable. RESULTS: The patients with RA had a greater presence of bacterial plaque, a greater periodontal pocket depth, a larger percentage of medium-sized pockets, and greater periodontal attachment loss compared with the controls. Likewise, a decrease in resting and stimulated saliva flow was observed, together with an increase in saliva IL-6 levels. Logistic regression analysis reported that the plaque index is the principal differentiating factor of patients with RA. Stimulated parotid saliva flow was also significantly correlated to the presence of RA. CONCLUSIONS: The patients with RA showed a greater tendency to develop periodontal disease than the controls, with lower salivary flow and higher levels of IL-6 in saliva. Key words:Rheumatoid arthritis, periodontal disease, saliva, IL-6.
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spelling pubmed-56941822017-11-22 Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study Silvestre-Rangil, Javier Bagán, Leticia Silvestre, Francisco-Javier Martinez-Herrera, Mayte Bagán, José-Vicente Med Oral Patol Oral Cir Bucal Research BACKGROUND: The aim of this study was to determine whether saliva interleukin-6 (IL-6) levels are elevated in patients with rheumatoid arthritis versus a control group and examine the possible relationship between the oral condition and the risk of RA. MATERIAL AND METHODS: In 30 patients with RA and 30 healthy controls, different periodontal indices were recorded; sialometric measurements were taken to determine resting whole saliva, stimulated whole saliva and stimulated parotid saliva flow; and the saliva IL-6 levels were measured. Logistic regression analysis was performed, with the presence or absence of RA as dependent variable. RESULTS: The patients with RA had a greater presence of bacterial plaque, a greater periodontal pocket depth, a larger percentage of medium-sized pockets, and greater periodontal attachment loss compared with the controls. Likewise, a decrease in resting and stimulated saliva flow was observed, together with an increase in saliva IL-6 levels. Logistic regression analysis reported that the plaque index is the principal differentiating factor of patients with RA. Stimulated parotid saliva flow was also significantly correlated to the presence of RA. CONCLUSIONS: The patients with RA showed a greater tendency to develop periodontal disease than the controls, with lower salivary flow and higher levels of IL-6 in saliva. Key words:Rheumatoid arthritis, periodontal disease, saliva, IL-6. Medicina Oral S.L. 2017-09 2017-08-16 /pmc/articles/PMC5694182/ /pubmed/28809379 http://dx.doi.org/10.4317/medoral.21937 Text en Copyright: © 2017 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Silvestre-Rangil, Javier
Bagán, Leticia
Silvestre, Francisco-Javier
Martinez-Herrera, Mayte
Bagán, José-Vicente
Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study
title Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study
title_full Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study
title_fullStr Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study
title_full_unstemmed Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study
title_short Periodontal, salivary and IL-6 status in rheumatoid arthritis patients. A cross-sectional study
title_sort periodontal, salivary and il-6 status in rheumatoid arthritis patients. a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694182/
https://www.ncbi.nlm.nih.gov/pubmed/28809379
http://dx.doi.org/10.4317/medoral.21937
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