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Strategies Developed to Induce, Direct, and Potentiate Bone Healing

Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies,...

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Autores principales: Collignon, Anne-Margaux, Lesieur, Julie, Vacher, Christian, Chaussain, Catherine, Rochefort, Gael Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694432/
https://www.ncbi.nlm.nih.gov/pubmed/29184512
http://dx.doi.org/10.3389/fphys.2017.00927
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author Collignon, Anne-Margaux
Lesieur, Julie
Vacher, Christian
Chaussain, Catherine
Rochefort, Gael Y.
author_facet Collignon, Anne-Margaux
Lesieur, Julie
Vacher, Christian
Chaussain, Catherine
Rochefort, Gael Y.
author_sort Collignon, Anne-Margaux
collection PubMed
description Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone. In this review, we browse the existing strategies that are currently developed, using biomolecules, cells and biomaterials, to induce, direct and potentiate bone healing after injury and further discuss the biological processes associated with this repair.
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spelling pubmed-56944322017-11-28 Strategies Developed to Induce, Direct, and Potentiate Bone Healing Collignon, Anne-Margaux Lesieur, Julie Vacher, Christian Chaussain, Catherine Rochefort, Gael Y. Front Physiol Physiology Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone. In this review, we browse the existing strategies that are currently developed, using biomolecules, cells and biomaterials, to induce, direct and potentiate bone healing after injury and further discuss the biological processes associated with this repair. Frontiers Media S.A. 2017-11-14 /pmc/articles/PMC5694432/ /pubmed/29184512 http://dx.doi.org/10.3389/fphys.2017.00927 Text en Copyright © 2017 Collignon, Lesieur, Vacher, Chaussain and Rochefort. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Collignon, Anne-Margaux
Lesieur, Julie
Vacher, Christian
Chaussain, Catherine
Rochefort, Gael Y.
Strategies Developed to Induce, Direct, and Potentiate Bone Healing
title Strategies Developed to Induce, Direct, and Potentiate Bone Healing
title_full Strategies Developed to Induce, Direct, and Potentiate Bone Healing
title_fullStr Strategies Developed to Induce, Direct, and Potentiate Bone Healing
title_full_unstemmed Strategies Developed to Induce, Direct, and Potentiate Bone Healing
title_short Strategies Developed to Induce, Direct, and Potentiate Bone Healing
title_sort strategies developed to induce, direct, and potentiate bone healing
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694432/
https://www.ncbi.nlm.nih.gov/pubmed/29184512
http://dx.doi.org/10.3389/fphys.2017.00927
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