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Strategies Developed to Induce, Direct, and Potentiate Bone Healing
Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694432/ https://www.ncbi.nlm.nih.gov/pubmed/29184512 http://dx.doi.org/10.3389/fphys.2017.00927 |
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author | Collignon, Anne-Margaux Lesieur, Julie Vacher, Christian Chaussain, Catherine Rochefort, Gael Y. |
author_facet | Collignon, Anne-Margaux Lesieur, Julie Vacher, Christian Chaussain, Catherine Rochefort, Gael Y. |
author_sort | Collignon, Anne-Margaux |
collection | PubMed |
description | Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone. In this review, we browse the existing strategies that are currently developed, using biomolecules, cells and biomaterials, to induce, direct and potentiate bone healing after injury and further discuss the biological processes associated with this repair. |
format | Online Article Text |
id | pubmed-5694432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56944322017-11-28 Strategies Developed to Induce, Direct, and Potentiate Bone Healing Collignon, Anne-Margaux Lesieur, Julie Vacher, Christian Chaussain, Catherine Rochefort, Gael Y. Front Physiol Physiology Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone. In this review, we browse the existing strategies that are currently developed, using biomolecules, cells and biomaterials, to induce, direct and potentiate bone healing after injury and further discuss the biological processes associated with this repair. Frontiers Media S.A. 2017-11-14 /pmc/articles/PMC5694432/ /pubmed/29184512 http://dx.doi.org/10.3389/fphys.2017.00927 Text en Copyright © 2017 Collignon, Lesieur, Vacher, Chaussain and Rochefort. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Collignon, Anne-Margaux Lesieur, Julie Vacher, Christian Chaussain, Catherine Rochefort, Gael Y. Strategies Developed to Induce, Direct, and Potentiate Bone Healing |
title | Strategies Developed to Induce, Direct, and Potentiate Bone Healing |
title_full | Strategies Developed to Induce, Direct, and Potentiate Bone Healing |
title_fullStr | Strategies Developed to Induce, Direct, and Potentiate Bone Healing |
title_full_unstemmed | Strategies Developed to Induce, Direct, and Potentiate Bone Healing |
title_short | Strategies Developed to Induce, Direct, and Potentiate Bone Healing |
title_sort | strategies developed to induce, direct, and potentiate bone healing |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694432/ https://www.ncbi.nlm.nih.gov/pubmed/29184512 http://dx.doi.org/10.3389/fphys.2017.00927 |
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