Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB(2) toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cell surface followed by internalization and transl...

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Detalles Bibliográficos
Autores principales: Boesze-Battaglia, Kathleen, Walker, Lisa P., Dhingra, Anuradha, Kandror, Konstantin, Tang, Hsin-Yao, Shenker, Bruce J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694546/
https://www.ncbi.nlm.nih.gov/pubmed/29184850
http://dx.doi.org/10.3389/fcimb.2017.00469

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