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Use of lipid emulsion therapy in local anesthetic overdose
The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although finding...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Saudi Medical Journal
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694647/ https://www.ncbi.nlm.nih.gov/pubmed/28917061 http://dx.doi.org/10.15537/smj.2017.10.20525 |
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author | Karcioglu, Ozgur |
author_facet | Karcioglu, Ozgur |
author_sort | Karcioglu, Ozgur |
collection | PubMed |
description | The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of severe impairment of cardiac functions, via a mechanism for trapping lipophilic drugs in an expanded plasma lipid compartment (“lipid sink”). In patients with hemodynamic compromise and/or cardiovascular collapse due to lipid-soluble agents, ILE may be considered for resuscitation in the acute setting by emergency physicians. The most common adverse effects from standard ILE include hypertriglyceridemia, fat embolism, infection, vein irritation, pancreatitis, electrolyte disturbances and allergic reactions. The advantages of ILE include an apparent wide margin of safety, relatively low cost, long shelf-life, and ease of administration. |
format | Online Article Text |
id | pubmed-5694647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-56946472017-11-27 Use of lipid emulsion therapy in local anesthetic overdose Karcioglu, Ozgur Saudi Med J Review Article The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of severe impairment of cardiac functions, via a mechanism for trapping lipophilic drugs in an expanded plasma lipid compartment (“lipid sink”). In patients with hemodynamic compromise and/or cardiovascular collapse due to lipid-soluble agents, ILE may be considered for resuscitation in the acute setting by emergency physicians. The most common adverse effects from standard ILE include hypertriglyceridemia, fat embolism, infection, vein irritation, pancreatitis, electrolyte disturbances and allergic reactions. The advantages of ILE include an apparent wide margin of safety, relatively low cost, long shelf-life, and ease of administration. Saudi Medical Journal 2017-10 /pmc/articles/PMC5694647/ /pubmed/28917061 http://dx.doi.org/10.15537/smj.2017.10.20525 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Karcioglu, Ozgur Use of lipid emulsion therapy in local anesthetic overdose |
title | Use of lipid emulsion therapy in local anesthetic overdose |
title_full | Use of lipid emulsion therapy in local anesthetic overdose |
title_fullStr | Use of lipid emulsion therapy in local anesthetic overdose |
title_full_unstemmed | Use of lipid emulsion therapy in local anesthetic overdose |
title_short | Use of lipid emulsion therapy in local anesthetic overdose |
title_sort | use of lipid emulsion therapy in local anesthetic overdose |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694647/ https://www.ncbi.nlm.nih.gov/pubmed/28917061 http://dx.doi.org/10.15537/smj.2017.10.20525 |
work_keys_str_mv | AT karciogluozgur useoflipidemulsiontherapyinlocalanestheticoverdose |