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Use of lipid emulsion therapy in local anesthetic overdose

The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although finding...

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Autor principal: Karcioglu, Ozgur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694647/
https://www.ncbi.nlm.nih.gov/pubmed/28917061
http://dx.doi.org/10.15537/smj.2017.10.20525
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author Karcioglu, Ozgur
author_facet Karcioglu, Ozgur
author_sort Karcioglu, Ozgur
collection PubMed
description The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of severe impairment of cardiac functions, via a mechanism for trapping lipophilic drugs in an expanded plasma lipid compartment (“lipid sink”). In patients with hemodynamic compromise and/or cardiovascular collapse due to lipid-soluble agents, ILE may be considered for resuscitation in the acute setting by emergency physicians. The most common adverse effects from standard ILE include hypertriglyceridemia, fat embolism, infection, vein irritation, pancreatitis, electrolyte disturbances and allergic reactions. The advantages of ILE include an apparent wide margin of safety, relatively low cost, long shelf-life, and ease of administration.
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spelling pubmed-56946472017-11-27 Use of lipid emulsion therapy in local anesthetic overdose Karcioglu, Ozgur Saudi Med J Review Article The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of severe impairment of cardiac functions, via a mechanism for trapping lipophilic drugs in an expanded plasma lipid compartment (“lipid sink”). In patients with hemodynamic compromise and/or cardiovascular collapse due to lipid-soluble agents, ILE may be considered for resuscitation in the acute setting by emergency physicians. The most common adverse effects from standard ILE include hypertriglyceridemia, fat embolism, infection, vein irritation, pancreatitis, electrolyte disturbances and allergic reactions. The advantages of ILE include an apparent wide margin of safety, relatively low cost, long shelf-life, and ease of administration. Saudi Medical Journal 2017-10 /pmc/articles/PMC5694647/ /pubmed/28917061 http://dx.doi.org/10.15537/smj.2017.10.20525 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Karcioglu, Ozgur
Use of lipid emulsion therapy in local anesthetic overdose
title Use of lipid emulsion therapy in local anesthetic overdose
title_full Use of lipid emulsion therapy in local anesthetic overdose
title_fullStr Use of lipid emulsion therapy in local anesthetic overdose
title_full_unstemmed Use of lipid emulsion therapy in local anesthetic overdose
title_short Use of lipid emulsion therapy in local anesthetic overdose
title_sort use of lipid emulsion therapy in local anesthetic overdose
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694647/
https://www.ncbi.nlm.nih.gov/pubmed/28917061
http://dx.doi.org/10.15537/smj.2017.10.20525
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