Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease

The CRISPR–Cas9 RNA-guided endonuclease system allows precise and efficient modification of complex genomes and is continuously developed to enhance specificity, alter targeting and add new functional moieties. However, one area yet to be explored is the base chemistry of the associated RNA molecule...

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Detalles Bibliográficos
Autores principales: Rueda, Fernando Orden, Bista, Michal, Newton, Matthew D., Goeppert, Anne U., Cuomo, M. Emanuela, Gordon, Euan, Kröner, Felix, Read, Jon A., Wrigley, Jonathan D., Rueda, David, Taylor, Benjamin J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694763/
https://www.ncbi.nlm.nih.gov/pubmed/29151576
http://dx.doi.org/10.1038/s41467-017-01732-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694763/
https://www.ncbi.nlm.nih.gov/pubmed/29151576
http://dx.doi.org/10.1038/s41467-017-01732-9

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