Balancing signals in the intestinal niche

During intestinal regeneration, opposing gradients of Wnt and BMP signaling ensure successful differentiation along the crypt/villus axis. In this issue of The EMBO Journal, Horiguchi et al (2017) show how intestinal subepithelial myofibroblasts can influence cell fate decisions in the regenerating...

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Detalles Bibliográficos
Autores principales: van Neerven, Sanne M, Vermeulen, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694942/
https://www.ncbi.nlm.nih.gov/pubmed/28159860
http://dx.doi.org/10.15252/embj.201796431
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author van Neerven, Sanne M
Vermeulen, Louis
author_facet van Neerven, Sanne M
Vermeulen, Louis
author_sort van Neerven, Sanne M
collection PubMed
description During intestinal regeneration, opposing gradients of Wnt and BMP signaling ensure successful differentiation along the crypt/villus axis. In this issue of The EMBO Journal, Horiguchi et al (2017) show how intestinal subepithelial myofibroblasts can influence cell fate decisions in the regenerating intestine via autocrine secretion of angiopoietin‐like protein 2 (ANGPTL2).
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spelling pubmed-56949422017-11-27 Balancing signals in the intestinal niche van Neerven, Sanne M Vermeulen, Louis EMBO J News & Views During intestinal regeneration, opposing gradients of Wnt and BMP signaling ensure successful differentiation along the crypt/villus axis. In this issue of The EMBO Journal, Horiguchi et al (2017) show how intestinal subepithelial myofibroblasts can influence cell fate decisions in the regenerating intestine via autocrine secretion of angiopoietin‐like protein 2 (ANGPTL2). John Wiley and Sons Inc. 2017-02-03 2017-02-15 /pmc/articles/PMC5694942/ /pubmed/28159860 http://dx.doi.org/10.15252/embj.201796431 Text en © 2017 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
van Neerven, Sanne M
Vermeulen, Louis
Balancing signals in the intestinal niche
title Balancing signals in the intestinal niche
title_full Balancing signals in the intestinal niche
title_fullStr Balancing signals in the intestinal niche
title_full_unstemmed Balancing signals in the intestinal niche
title_short Balancing signals in the intestinal niche
title_sort balancing signals in the intestinal niche
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694942/
https://www.ncbi.nlm.nih.gov/pubmed/28159860
http://dx.doi.org/10.15252/embj.201796431
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