Transforming doxorubicin into a cancer stem cell killer via EpCAM aptamer-mediated delivery

Chemotherapy-resistant cancer stem cells (CSCs) are a major obstacle to the effective treatment of many forms of cancer. To overcome CSC chemo-resistance, we developed a novel system by conjugating a CSC-targeting EpCAM aptamer with doxorubicin (Apt-DOX) to eliminate CSCs. Incubation of Apt-DOX with...

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Detalles Bibliográficos
Autores principales: Xiang, Dongxi, Shigdar, Sarah, Bean, Andrew G, Bruce, Matthew, Yang, Wenrong, Mathesh, Motilal, Wang, Tao, Yin, Wang, Tran, Phuong Ha-Lien, Al Shamaileh, Hadi, Barrero, Roberto A, Zhang, Pei-Zhuo, Li, Yong, Kong, Lingxue, Liu, Ke, Zhou, Shu-Feng, Hou, Yingchun, He, Aina, Duan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694998/
https://www.ncbi.nlm.nih.gov/pubmed/29158811
http://dx.doi.org/10.7150/thno.20168

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