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Extracellular Vesicles in Cardiovascular Theranostics
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in targ...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695004/ https://www.ncbi.nlm.nih.gov/pubmed/29158817 http://dx.doi.org/10.7150/thno.21274 |
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author | Bei, Yihua Das, Saumya Rodosthenous, Rodosthenis S. Holvoet, Paul Vanhaverbeke, Maarten Monteiro, Marta Chagas Monteiro, Valter Vinicius Silva Radosinska, Jana Bartekova, Monika Jansen, Felix Li, Qian Rajasingh, Johnson Xiao, Junjie |
author_facet | Bei, Yihua Das, Saumya Rodosthenous, Rodosthenis S. Holvoet, Paul Vanhaverbeke, Maarten Monteiro, Marta Chagas Monteiro, Valter Vinicius Silva Radosinska, Jana Bartekova, Monika Jansen, Felix Li, Qian Rajasingh, Johnson Xiao, Junjie |
author_sort | Bei, Yihua |
collection | PubMed |
description | Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs. In this review, we will first outline the current knowledge about the physical characteristics, biological contents, and isolation methods of EVs. We will then focus on the functional roles of cardiovascular EVs and their pathophysiological effects in CVDs, as well as summarize the potential of EVs as therapeutic agents and biomarkers for CVDs. Finally, we will discuss the specific application of EVs as a novel drug delivery system and the utility of EVs in the field of regenerative medicine. |
format | Online Article Text |
id | pubmed-5695004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-56950042017-11-20 Extracellular Vesicles in Cardiovascular Theranostics Bei, Yihua Das, Saumya Rodosthenous, Rodosthenis S. Holvoet, Paul Vanhaverbeke, Maarten Monteiro, Marta Chagas Monteiro, Valter Vinicius Silva Radosinska, Jana Bartekova, Monika Jansen, Felix Li, Qian Rajasingh, Johnson Xiao, Junjie Theranostics Review Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs. In this review, we will first outline the current knowledge about the physical characteristics, biological contents, and isolation methods of EVs. We will then focus on the functional roles of cardiovascular EVs and their pathophysiological effects in CVDs, as well as summarize the potential of EVs as therapeutic agents and biomarkers for CVDs. Finally, we will discuss the specific application of EVs as a novel drug delivery system and the utility of EVs in the field of regenerative medicine. Ivyspring International Publisher 2017-09-26 /pmc/articles/PMC5695004/ /pubmed/29158817 http://dx.doi.org/10.7150/thno.21274 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Bei, Yihua Das, Saumya Rodosthenous, Rodosthenis S. Holvoet, Paul Vanhaverbeke, Maarten Monteiro, Marta Chagas Monteiro, Valter Vinicius Silva Radosinska, Jana Bartekova, Monika Jansen, Felix Li, Qian Rajasingh, Johnson Xiao, Junjie Extracellular Vesicles in Cardiovascular Theranostics |
title | Extracellular Vesicles in Cardiovascular Theranostics |
title_full | Extracellular Vesicles in Cardiovascular Theranostics |
title_fullStr | Extracellular Vesicles in Cardiovascular Theranostics |
title_full_unstemmed | Extracellular Vesicles in Cardiovascular Theranostics |
title_short | Extracellular Vesicles in Cardiovascular Theranostics |
title_sort | extracellular vesicles in cardiovascular theranostics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695004/ https://www.ncbi.nlm.nih.gov/pubmed/29158817 http://dx.doi.org/10.7150/thno.21274 |
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