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Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy

Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the s...

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Autores principales: Wang, Dongdong, Zhou, Jiajia, Shi, Ruohong, Wu, Huihui, Chen, Ruhui, Duan, Beichen, Xia, Guoliang, Xu, Pengping, Wang, Hui, Zhou, Shu, Wang, Chengming, Wang, Haibao, Guo, Zhen, Chen, Qianwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695152/
https://www.ncbi.nlm.nih.gov/pubmed/29158848
http://dx.doi.org/10.7150/thno.20363
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author Wang, Dongdong
Zhou, Jiajia
Shi, Ruohong
Wu, Huihui
Chen, Ruhui
Duan, Beichen
Xia, Guoliang
Xu, Pengping
Wang, Hui
Zhou, Shu
Wang, Chengming
Wang, Haibao
Guo, Zhen
Chen, Qianwang
author_facet Wang, Dongdong
Zhou, Jiajia
Shi, Ruohong
Wu, Huihui
Chen, Ruhui
Duan, Beichen
Xia, Guoliang
Xu, Pengping
Wang, Hui
Zhou, Shu
Wang, Chengming
Wang, Haibao
Guo, Zhen
Chen, Qianwang
author_sort Wang, Dongdong
collection PubMed
description Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach. With Prussian blue as core, CSD-MOFs are able to serve as both magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) agents. We show that CSD-MOFs crystals loading the anticancer drug doxorubicin (DOX) are efficient pH and near-infrared (NIR) dual-stimuli responsive drug delivery vehicles. After the degradation of ZIF-8, simultaneous NIR irradiation to the inner PB MOFs continuously generate heat that kill cancer cells. Their efficacy on HeLa cancer cell lines is higher compared with the respective single treatment modality, achieving synergistic chemo-thermal therapy efficacy. In vivo results indicate that the anti-tumor efficacy of CSD-MOFs@DOX+NIR was 7.16 and 5.07 times enhanced compared to single chemo-therapy and single thermal-therapy respectively. Our strategy opens new possibilities to construct multifunctional theranostic systems through integration of two different MOFs.
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spelling pubmed-56951522017-11-20 Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy Wang, Dongdong Zhou, Jiajia Shi, Ruohong Wu, Huihui Chen, Ruhui Duan, Beichen Xia, Guoliang Xu, Pengping Wang, Hui Zhou, Shu Wang, Chengming Wang, Haibao Guo, Zhen Chen, Qianwang Theranostics Research Paper Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach. With Prussian blue as core, CSD-MOFs are able to serve as both magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) agents. We show that CSD-MOFs crystals loading the anticancer drug doxorubicin (DOX) are efficient pH and near-infrared (NIR) dual-stimuli responsive drug delivery vehicles. After the degradation of ZIF-8, simultaneous NIR irradiation to the inner PB MOFs continuously generate heat that kill cancer cells. Their efficacy on HeLa cancer cell lines is higher compared with the respective single treatment modality, achieving synergistic chemo-thermal therapy efficacy. In vivo results indicate that the anti-tumor efficacy of CSD-MOFs@DOX+NIR was 7.16 and 5.07 times enhanced compared to single chemo-therapy and single thermal-therapy respectively. Our strategy opens new possibilities to construct multifunctional theranostic systems through integration of two different MOFs. Ivyspring International Publisher 2017-10-13 /pmc/articles/PMC5695152/ /pubmed/29158848 http://dx.doi.org/10.7150/thno.20363 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Dongdong
Zhou, Jiajia
Shi, Ruohong
Wu, Huihui
Chen, Ruhui
Duan, Beichen
Xia, Guoliang
Xu, Pengping
Wang, Hui
Zhou, Shu
Wang, Chengming
Wang, Haibao
Guo, Zhen
Chen, Qianwang
Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
title Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
title_full Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
title_fullStr Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
title_full_unstemmed Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
title_short Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
title_sort biodegradable core-shell dual-metal-organic-frameworks nanotheranostic agent for multiple imaging guided combination cancer therapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695152/
https://www.ncbi.nlm.nih.gov/pubmed/29158848
http://dx.doi.org/10.7150/thno.20363
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