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The efficacy of antipsychotics for prolonged delirium with renal dysfunction

AIM: Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization. METHODS: We extracted all new inpatients (n=523) cons...

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Autores principales: Asano, Satoko, Kunii, Yasuto, Hoshino, Hiroshi, Osakabe, Yusuke, Shiga, Tetsuya, Itagaki, Shuntaro, Miura, Itaru, Yabe, Hirooki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695253/
https://www.ncbi.nlm.nih.gov/pubmed/29180868
http://dx.doi.org/10.2147/NDT.S147701
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author Asano, Satoko
Kunii, Yasuto
Hoshino, Hiroshi
Osakabe, Yusuke
Shiga, Tetsuya
Itagaki, Shuntaro
Miura, Itaru
Yabe, Hirooki
author_facet Asano, Satoko
Kunii, Yasuto
Hoshino, Hiroshi
Osakabe, Yusuke
Shiga, Tetsuya
Itagaki, Shuntaro
Miura, Itaru
Yabe, Hirooki
author_sort Asano, Satoko
collection PubMed
description AIM: Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization. METHODS: We extracted all new inpatients (n=523) consulted for psychiatric symptoms at Fukushima Medical University Hospital between October 2011 and September 2013. We selected 203 inpatients with delirium diagnosed by psychiatrists. We analyzed data from 177 inpatients with delirium who received psychiatric medication. We defined an “early improvement group” in which delirium resolved in ≤3 days after starting psychiatric medication, and a “prolonged group” with delirium lasting for >3 days. Among the 83 inpatients with renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m(2)), we defined an “early improvement group with renal dysfunction” in which delirium resolved in ≤3 days after starting psychiatric medication and a “prolonged group with renal dysfunction” with delirium lasting for >3 days. We then examined differences between groups for different categorical variables. RESULTS: Dose of antipsychotic medication at end point was significantly lower in the prolonged group with renal dysfunction than in the early improvement group with renal dysfunction. CONCLUSION: The results suggest that maintaining a sufficient dose of antipsychotics from an early stage may prevent prolongation of delirium even in inpatients with renal dysfunction.
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spelling pubmed-56952532017-11-27 The efficacy of antipsychotics for prolonged delirium with renal dysfunction Asano, Satoko Kunii, Yasuto Hoshino, Hiroshi Osakabe, Yusuke Shiga, Tetsuya Itagaki, Shuntaro Miura, Itaru Yabe, Hirooki Neuropsychiatr Dis Treat Original Research AIM: Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization. METHODS: We extracted all new inpatients (n=523) consulted for psychiatric symptoms at Fukushima Medical University Hospital between October 2011 and September 2013. We selected 203 inpatients with delirium diagnosed by psychiatrists. We analyzed data from 177 inpatients with delirium who received psychiatric medication. We defined an “early improvement group” in which delirium resolved in ≤3 days after starting psychiatric medication, and a “prolonged group” with delirium lasting for >3 days. Among the 83 inpatients with renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m(2)), we defined an “early improvement group with renal dysfunction” in which delirium resolved in ≤3 days after starting psychiatric medication and a “prolonged group with renal dysfunction” with delirium lasting for >3 days. We then examined differences between groups for different categorical variables. RESULTS: Dose of antipsychotic medication at end point was significantly lower in the prolonged group with renal dysfunction than in the early improvement group with renal dysfunction. CONCLUSION: The results suggest that maintaining a sufficient dose of antipsychotics from an early stage may prevent prolongation of delirium even in inpatients with renal dysfunction. Dove Medical Press 2017-11-16 /pmc/articles/PMC5695253/ /pubmed/29180868 http://dx.doi.org/10.2147/NDT.S147701 Text en © 2017 Asano et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Asano, Satoko
Kunii, Yasuto
Hoshino, Hiroshi
Osakabe, Yusuke
Shiga, Tetsuya
Itagaki, Shuntaro
Miura, Itaru
Yabe, Hirooki
The efficacy of antipsychotics for prolonged delirium with renal dysfunction
title The efficacy of antipsychotics for prolonged delirium with renal dysfunction
title_full The efficacy of antipsychotics for prolonged delirium with renal dysfunction
title_fullStr The efficacy of antipsychotics for prolonged delirium with renal dysfunction
title_full_unstemmed The efficacy of antipsychotics for prolonged delirium with renal dysfunction
title_short The efficacy of antipsychotics for prolonged delirium with renal dysfunction
title_sort efficacy of antipsychotics for prolonged delirium with renal dysfunction
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695253/
https://www.ncbi.nlm.nih.gov/pubmed/29180868
http://dx.doi.org/10.2147/NDT.S147701
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