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A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammar...

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Detalles Bibliográficos
Autores principales:	Oakes, Samantha R., Gallego-Ortega, David, Stanford, Prudence M., Junankar, Simon, Au, Wendy Wing Yee, Kikhtyak, Zoya, von Korff, Anita, Sergio, Claudio M., Law, Andrew M. K., Castillo, Lesley E., Allerdice, Stephanie L., Young, Adelaide I. J., Piggin, Catherine, Whittle, Belinda, Bertram, Edward, Naylor, Matthew J., Roden, Daniel L., Donovan, Jesse, Korennykh, Alexei, Goodnow, Christopher C., O’Bryan, Moira K., Ormandy, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695588/ https://www.ncbi.nlm.nih.gov/pubmed/29117179 http://dx.doi.org/10.1371/journal.pgen.1007072

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