Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections

Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunolog...

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Autores principales: Crum-Cianflone, Nancy F, Lam, Pamela V, Ross-Walker, Sarah, Rosen, Lindsey B, Holland, Steven M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695620/
https://www.ncbi.nlm.nih.gov/pubmed/29181420
http://dx.doi.org/10.1093/ofid/ofx211
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author Crum-Cianflone, Nancy F
Lam, Pamela V
Ross-Walker, Sarah
Rosen, Lindsey B
Holland, Steven M
author_facet Crum-Cianflone, Nancy F
Lam, Pamela V
Ross-Walker, Sarah
Rosen, Lindsey B
Holland, Steven M
author_sort Crum-Cianflone, Nancy F
collection PubMed
description Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling.
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spelling pubmed-56956202017-11-27 Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections Crum-Cianflone, Nancy F Lam, Pamela V Ross-Walker, Sarah Rosen, Lindsey B Holland, Steven M Open Forum Infect Dis Brief Report Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling. Oxford University Press 2017-10-05 /pmc/articles/PMC5695620/ /pubmed/29181420 http://dx.doi.org/10.1093/ofid/ofx211 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Crum-Cianflone, Nancy F
Lam, Pamela V
Ross-Walker, Sarah
Rosen, Lindsey B
Holland, Steven M
Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
title Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
title_full Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
title_fullStr Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
title_full_unstemmed Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
title_short Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
title_sort autoantibodies to granulocyte-macrophage colony-stimulating factor associated with severe and unusual manifestations of cryptococcus gattii infections
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695620/
https://www.ncbi.nlm.nih.gov/pubmed/29181420
http://dx.doi.org/10.1093/ofid/ofx211
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