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Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling

Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis. Group 3 innate lymphocytes (ILC3s) are important in mucosal barrier maintenance due to...

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Detalles Bibliográficos
Autores principales: Seshadri, Sudarshan, Allan, David S. J., Carlyle, James R., Zenewicz, Lauren A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695638/
https://www.ncbi.nlm.nih.gov/pubmed/29059238
http://dx.doi.org/10.1371/journal.ppat.1006690