Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections

Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different cli...

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Detalles Bibliográficos
Autores principales: Lidsky, Peter V, Andino, Raul, Rouzine, Igor M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695700/
https://www.ncbi.nlm.nih.gov/pubmed/28551476
http://dx.doi.org/10.1016/j.coviro.2017.05.001
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author Lidsky, Peter V
Andino, Raul
Rouzine, Igor M
author_facet Lidsky, Peter V
Andino, Raul
Rouzine, Igor M
author_sort Lidsky, Peter V
collection PubMed
description Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction.
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spelling pubmed-56957002018-05-25 Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections Lidsky, Peter V Andino, Raul Rouzine, Igor M Curr Opin Virol Article Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction. Elsevier B.V. 2017-04 2017-05-25 /pmc/articles/PMC5695700/ /pubmed/28551476 http://dx.doi.org/10.1016/j.coviro.2017.05.001 Text en © 2017 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lidsky, Peter V
Andino, Raul
Rouzine, Igor M
Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
title Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
title_full Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
title_fullStr Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
title_full_unstemmed Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
title_short Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
title_sort variability in viral pathogenesis: modeling the dynamic of acute and persistent infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695700/
https://www.ncbi.nlm.nih.gov/pubmed/28551476
http://dx.doi.org/10.1016/j.coviro.2017.05.001
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