Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase

It has recently been shown that signal peptide peptidase (SPP) can catalyze the intramembrane cleavage of heme oxygenase-1 (HO-1) that leads to translocation of HO-1 into the cytosol and nucleus. While there is consensus that translocated HO-1 promotes tumor progression and drug resistance, the phys...

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Detalles Bibliográficos
Autores principales: Schaefer, Bianca, Moriishi, Kohji, Behrends, Soenke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695791/
https://www.ncbi.nlm.nih.gov/pubmed/29155886
http://dx.doi.org/10.1371/journal.pone.0188344

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