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The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks

Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes i...

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Detalles Bibliográficos
Autores principales: Clarke, Kim, Ricciardi, Sara, Pearson, Tim, Bharudin, Izwan, Davidsen, Peter K., Bonomo, Michela, Brina, Daniela, Scagliola, Alessandra, Simpson, Deborah M., Beynon, Robert J., Khanim, Farhat, Ankers, John, Sarzynski, Mark A., Ghosh, Sujoy, Pisconti, Addolorata, Rozman, Jan, Hrabe de Angelis, Martin, Bunce, Chris, Stewart, Claire, Egginton, Stuart, Caddick, Mark, Jackson, Malcolm, Bouchard, Claude, Biffo, Stefano, Falciani, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695912/
https://www.ncbi.nlm.nih.gov/pubmed/29117557
http://dx.doi.org/10.1016/j.celrep.2017.10.040
Descripción
Sumario:Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes in gene regulatory networks linking signaling and selective control of translation to energy metabolism and tissue remodeling. We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS production, and exercise performance. Our work demonstrates the validity of a data-driven approach to understanding muscle homeostasis.