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Biomarkers identified for prostate cancer patients through genome-scale screening
Prostate cancer is a threat to men and usually occurs in aged males. Though prostate specific antigen level and Gleason score are utilized for evaluation of the prostate cancer in clinic, the biomarkers for this malignancy have not been widely recognized. Furthermore, the outcome varies across indiv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696163/ https://www.ncbi.nlm.nih.gov/pubmed/29190897 http://dx.doi.org/10.18632/oncotarget.20739 |
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author | Wang, Lei-Yun Cui, Jia-Jia Zhu, Tao Shao, Wei-Hua Zhao, Yi Wang, Sai Zhang, Yu-Peng Wu, Ji-Chu Zhang, Le |
author_facet | Wang, Lei-Yun Cui, Jia-Jia Zhu, Tao Shao, Wei-Hua Zhao, Yi Wang, Sai Zhang, Yu-Peng Wu, Ji-Chu Zhang, Le |
author_sort | Wang, Lei-Yun |
collection | PubMed |
description | Prostate cancer is a threat to men and usually occurs in aged males. Though prostate specific antigen level and Gleason score are utilized for evaluation of the prostate cancer in clinic, the biomarkers for this malignancy have not been widely recognized. Furthermore, the outcome varies across individuals receiving comparable treatment regimens and the underlying mechanism is still unclear. We supposed that genetic feature may be responsible for, at least in part, this process and conducted a two-cohort study to compare the genetic difference in tumorous and normal tissues of prostate cancer patients. The Gene Expression Omnibus dataset were used and a total of 41 genes were found significantly differently expressed in tumor tissues as compared with normal prostate tissues. Four genes (SPOCK3, SPON1, PTN and TGFB3) were selected for further evaluation after Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis and clinical association analysis. MIR1908 was also found decreased expression level in prostate cancer whose target genes were found expressing in both prostate tumor and normal tissues. These results indicated that these potential biomarkers deserve attention in prostate cancer patients and the underlying mechanism should be further investigated. |
format | Online Article Text |
id | pubmed-5696163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56961632017-11-29 Biomarkers identified for prostate cancer patients through genome-scale screening Wang, Lei-Yun Cui, Jia-Jia Zhu, Tao Shao, Wei-Hua Zhao, Yi Wang, Sai Zhang, Yu-Peng Wu, Ji-Chu Zhang, Le Oncotarget Research Paper Prostate cancer is a threat to men and usually occurs in aged males. Though prostate specific antigen level and Gleason score are utilized for evaluation of the prostate cancer in clinic, the biomarkers for this malignancy have not been widely recognized. Furthermore, the outcome varies across individuals receiving comparable treatment regimens and the underlying mechanism is still unclear. We supposed that genetic feature may be responsible for, at least in part, this process and conducted a two-cohort study to compare the genetic difference in tumorous and normal tissues of prostate cancer patients. The Gene Expression Omnibus dataset were used and a total of 41 genes were found significantly differently expressed in tumor tissues as compared with normal prostate tissues. Four genes (SPOCK3, SPON1, PTN and TGFB3) were selected for further evaluation after Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis and clinical association analysis. MIR1908 was also found decreased expression level in prostate cancer whose target genes were found expressing in both prostate tumor and normal tissues. These results indicated that these potential biomarkers deserve attention in prostate cancer patients and the underlying mechanism should be further investigated. Impact Journals LLC 2017-09-08 /pmc/articles/PMC5696163/ /pubmed/29190897 http://dx.doi.org/10.18632/oncotarget.20739 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Wang, Lei-Yun Cui, Jia-Jia Zhu, Tao Shao, Wei-Hua Zhao, Yi Wang, Sai Zhang, Yu-Peng Wu, Ji-Chu Zhang, Le Biomarkers identified for prostate cancer patients through genome-scale screening |
title | Biomarkers identified for prostate cancer patients through genome-scale screening |
title_full | Biomarkers identified for prostate cancer patients through genome-scale screening |
title_fullStr | Biomarkers identified for prostate cancer patients through genome-scale screening |
title_full_unstemmed | Biomarkers identified for prostate cancer patients through genome-scale screening |
title_short | Biomarkers identified for prostate cancer patients through genome-scale screening |
title_sort | biomarkers identified for prostate cancer patients through genome-scale screening |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696163/ https://www.ncbi.nlm.nih.gov/pubmed/29190897 http://dx.doi.org/10.18632/oncotarget.20739 |
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