Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696172/ https://www.ncbi.nlm.nih.gov/pubmed/29190906 http://dx.doi.org/10.18632/oncotarget.20988 |
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author | Hong, Junshik Kim, Seok Jin Chang, Myung Hee Kim, Jeong-A Kwak, Jae-Yong Kim, Jin Seok Yoon, Dok Hyun Lee, Won Sik Do, Young Rok Kang, Hye Jin Eom, Hyeon-Seok Park, Yong Won, Jong-Ho Mun, Yeung-Chul Kim, Hyo Jung Kwon, Jung Hye Kong, Jee Hyun Oh, Sung Yong Lee, Sunah Bae, Sung Hwa Yang, Deok-Hwan Jun, Hyun Jung Lee, Ho Sup Yun, Hwan Jung Lee, Soon Il Kim, Min Kyoung Yi, Jun Ho Lee, Jae Hoon Kim, Won Seog Suh, Cheolwon |
author_facet | Hong, Junshik Kim, Seok Jin Chang, Myung Hee Kim, Jeong-A Kwak, Jae-Yong Kim, Jin Seok Yoon, Dok Hyun Lee, Won Sik Do, Young Rok Kang, Hye Jin Eom, Hyeon-Seok Park, Yong Won, Jong-Ho Mun, Yeung-Chul Kim, Hyo Jung Kwon, Jung Hye Kong, Jee Hyun Oh, Sung Yong Lee, Sunah Bae, Sung Hwa Yang, Deok-Hwan Jun, Hyun Jung Lee, Ho Sup Yun, Hwan Jung Lee, Soon Il Kim, Min Kyoung Yi, Jun Ho Lee, Jae Hoon Kim, Won Seog Suh, Cheolwon |
author_sort | Hong, Junshik |
collection | PubMed |
description | The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the effectiveness of risk prediction between IPI, NCCN-IPI, and GELTAMO-IPI in patients with DLBCL particularly in terms of determining high-risk patients. Among 439 patients who were enrolled to a prospective DLBCL cohort treated with R-CHOP immunochemotherapy, risk groups were classified according to the three IPIs and the prognostic significance of individual IPI factors and IPI models were analyzed and compared. All three IPI effectively separated the analyzed patients into four risk groups according to overall survival (OS). Estimated 5-year OS of patients classified as high-risk according to the IPI was 45.7%, suggesting that the IPI is limited in the selection of patients who are expected to have a poor outcome. In contrast, the 5-year OS of patients stratified as high-risk according to NCCN- and GELTAMO-IPI was 31.4% and 21.9%, respectively. The results indicate that NCCN- and GELTAMO-IPI are better than the IPI in predicting patients with poor prognosis, suggesting the superiority of enhanced, next-generation IPIs for DLBCL. |
format | Online Article Text |
id | pubmed-5696172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56961722017-11-29 Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma Hong, Junshik Kim, Seok Jin Chang, Myung Hee Kim, Jeong-A Kwak, Jae-Yong Kim, Jin Seok Yoon, Dok Hyun Lee, Won Sik Do, Young Rok Kang, Hye Jin Eom, Hyeon-Seok Park, Yong Won, Jong-Ho Mun, Yeung-Chul Kim, Hyo Jung Kwon, Jung Hye Kong, Jee Hyun Oh, Sung Yong Lee, Sunah Bae, Sung Hwa Yang, Deok-Hwan Jun, Hyun Jung Lee, Ho Sup Yun, Hwan Jung Lee, Soon Il Kim, Min Kyoung Yi, Jun Ho Lee, Jae Hoon Kim, Won Seog Suh, Cheolwon Oncotarget Research Paper The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the effectiveness of risk prediction between IPI, NCCN-IPI, and GELTAMO-IPI in patients with DLBCL particularly in terms of determining high-risk patients. Among 439 patients who were enrolled to a prospective DLBCL cohort treated with R-CHOP immunochemotherapy, risk groups were classified according to the three IPIs and the prognostic significance of individual IPI factors and IPI models were analyzed and compared. All three IPI effectively separated the analyzed patients into four risk groups according to overall survival (OS). Estimated 5-year OS of patients classified as high-risk according to the IPI was 45.7%, suggesting that the IPI is limited in the selection of patients who are expected to have a poor outcome. In contrast, the 5-year OS of patients stratified as high-risk according to NCCN- and GELTAMO-IPI was 31.4% and 21.9%, respectively. The results indicate that NCCN- and GELTAMO-IPI are better than the IPI in predicting patients with poor prognosis, suggesting the superiority of enhanced, next-generation IPIs for DLBCL. Impact Journals LLC 2017-09-18 /pmc/articles/PMC5696172/ /pubmed/29190906 http://dx.doi.org/10.18632/oncotarget.20988 Text en Copyright: © 2017 Hong et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Hong, Junshik Kim, Seok Jin Chang, Myung Hee Kim, Jeong-A Kwak, Jae-Yong Kim, Jin Seok Yoon, Dok Hyun Lee, Won Sik Do, Young Rok Kang, Hye Jin Eom, Hyeon-Seok Park, Yong Won, Jong-Ho Mun, Yeung-Chul Kim, Hyo Jung Kwon, Jung Hye Kong, Jee Hyun Oh, Sung Yong Lee, Sunah Bae, Sung Hwa Yang, Deok-Hwan Jun, Hyun Jung Lee, Ho Sup Yun, Hwan Jung Lee, Soon Il Kim, Min Kyoung Yi, Jun Ho Lee, Jae Hoon Kim, Won Seog Suh, Cheolwon Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma |
title | Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma |
title_full | Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma |
title_fullStr | Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma |
title_full_unstemmed | Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma |
title_short | Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma |
title_sort | improved prognostic stratification using nccn- and geltamo-international prognostic index in patients with diffuse large b-cell lymphoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696172/ https://www.ncbi.nlm.nih.gov/pubmed/29190906 http://dx.doi.org/10.18632/oncotarget.20988 |
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