Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma

The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the...

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Autores principales: Hong, Junshik, Kim, Seok Jin, Chang, Myung Hee, Kim, Jeong-A, Kwak, Jae-Yong, Kim, Jin Seok, Yoon, Dok Hyun, Lee, Won Sik, Do, Young Rok, Kang, Hye Jin, Eom, Hyeon-Seok, Park, Yong, Won, Jong-Ho, Mun, Yeung-Chul, Kim, Hyo Jung, Kwon, Jung Hye, Kong, Jee Hyun, Oh, Sung Yong, Lee, Sunah, Bae, Sung Hwa, Yang, Deok-Hwan, Jun, Hyun Jung, Lee, Ho Sup, Yun, Hwan Jung, Lee, Soon Il, Kim, Min Kyoung, Yi, Jun Ho, Lee, Jae Hoon, Kim, Won Seog, Suh, Cheolwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696172/
https://www.ncbi.nlm.nih.gov/pubmed/29190906
http://dx.doi.org/10.18632/oncotarget.20988
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author Hong, Junshik
Kim, Seok Jin
Chang, Myung Hee
Kim, Jeong-A
Kwak, Jae-Yong
Kim, Jin Seok
Yoon, Dok Hyun
Lee, Won Sik
Do, Young Rok
Kang, Hye Jin
Eom, Hyeon-Seok
Park, Yong
Won, Jong-Ho
Mun, Yeung-Chul
Kim, Hyo Jung
Kwon, Jung Hye
Kong, Jee Hyun
Oh, Sung Yong
Lee, Sunah
Bae, Sung Hwa
Yang, Deok-Hwan
Jun, Hyun Jung
Lee, Ho Sup
Yun, Hwan Jung
Lee, Soon Il
Kim, Min Kyoung
Yi, Jun Ho
Lee, Jae Hoon
Kim, Won Seog
Suh, Cheolwon
author_facet Hong, Junshik
Kim, Seok Jin
Chang, Myung Hee
Kim, Jeong-A
Kwak, Jae-Yong
Kim, Jin Seok
Yoon, Dok Hyun
Lee, Won Sik
Do, Young Rok
Kang, Hye Jin
Eom, Hyeon-Seok
Park, Yong
Won, Jong-Ho
Mun, Yeung-Chul
Kim, Hyo Jung
Kwon, Jung Hye
Kong, Jee Hyun
Oh, Sung Yong
Lee, Sunah
Bae, Sung Hwa
Yang, Deok-Hwan
Jun, Hyun Jung
Lee, Ho Sup
Yun, Hwan Jung
Lee, Soon Il
Kim, Min Kyoung
Yi, Jun Ho
Lee, Jae Hoon
Kim, Won Seog
Suh, Cheolwon
author_sort Hong, Junshik
collection PubMed
description The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the effectiveness of risk prediction between IPI, NCCN-IPI, and GELTAMO-IPI in patients with DLBCL particularly in terms of determining high-risk patients. Among 439 patients who were enrolled to a prospective DLBCL cohort treated with R-CHOP immunochemotherapy, risk groups were classified according to the three IPIs and the prognostic significance of individual IPI factors and IPI models were analyzed and compared. All three IPI effectively separated the analyzed patients into four risk groups according to overall survival (OS). Estimated 5-year OS of patients classified as high-risk according to the IPI was 45.7%, suggesting that the IPI is limited in the selection of patients who are expected to have a poor outcome. In contrast, the 5-year OS of patients stratified as high-risk according to NCCN- and GELTAMO-IPI was 31.4% and 21.9%, respectively. The results indicate that NCCN- and GELTAMO-IPI are better than the IPI in predicting patients with poor prognosis, suggesting the superiority of enhanced, next-generation IPIs for DLBCL.
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spelling pubmed-56961722017-11-29 Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma Hong, Junshik Kim, Seok Jin Chang, Myung Hee Kim, Jeong-A Kwak, Jae-Yong Kim, Jin Seok Yoon, Dok Hyun Lee, Won Sik Do, Young Rok Kang, Hye Jin Eom, Hyeon-Seok Park, Yong Won, Jong-Ho Mun, Yeung-Chul Kim, Hyo Jung Kwon, Jung Hye Kong, Jee Hyun Oh, Sung Yong Lee, Sunah Bae, Sung Hwa Yang, Deok-Hwan Jun, Hyun Jung Lee, Ho Sup Yun, Hwan Jung Lee, Soon Il Kim, Min Kyoung Yi, Jun Ho Lee, Jae Hoon Kim, Won Seog Suh, Cheolwon Oncotarget Research Paper The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the effectiveness of risk prediction between IPI, NCCN-IPI, and GELTAMO-IPI in patients with DLBCL particularly in terms of determining high-risk patients. Among 439 patients who were enrolled to a prospective DLBCL cohort treated with R-CHOP immunochemotherapy, risk groups were classified according to the three IPIs and the prognostic significance of individual IPI factors and IPI models were analyzed and compared. All three IPI effectively separated the analyzed patients into four risk groups according to overall survival (OS). Estimated 5-year OS of patients classified as high-risk according to the IPI was 45.7%, suggesting that the IPI is limited in the selection of patients who are expected to have a poor outcome. In contrast, the 5-year OS of patients stratified as high-risk according to NCCN- and GELTAMO-IPI was 31.4% and 21.9%, respectively. The results indicate that NCCN- and GELTAMO-IPI are better than the IPI in predicting patients with poor prognosis, suggesting the superiority of enhanced, next-generation IPIs for DLBCL. Impact Journals LLC 2017-09-18 /pmc/articles/PMC5696172/ /pubmed/29190906 http://dx.doi.org/10.18632/oncotarget.20988 Text en Copyright: © 2017 Hong et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Hong, Junshik
Kim, Seok Jin
Chang, Myung Hee
Kim, Jeong-A
Kwak, Jae-Yong
Kim, Jin Seok
Yoon, Dok Hyun
Lee, Won Sik
Do, Young Rok
Kang, Hye Jin
Eom, Hyeon-Seok
Park, Yong
Won, Jong-Ho
Mun, Yeung-Chul
Kim, Hyo Jung
Kwon, Jung Hye
Kong, Jee Hyun
Oh, Sung Yong
Lee, Sunah
Bae, Sung Hwa
Yang, Deok-Hwan
Jun, Hyun Jung
Lee, Ho Sup
Yun, Hwan Jung
Lee, Soon Il
Kim, Min Kyoung
Yi, Jun Ho
Lee, Jae Hoon
Kim, Won Seog
Suh, Cheolwon
Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
title Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
title_full Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
title_fullStr Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
title_full_unstemmed Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
title_short Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
title_sort improved prognostic stratification using nccn- and geltamo-international prognostic index in patients with diffuse large b-cell lymphoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696172/
https://www.ncbi.nlm.nih.gov/pubmed/29190906
http://dx.doi.org/10.18632/oncotarget.20988
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