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Acquisition of EGFR TKI resistance and EMT phenotype is linked with activation of IGF1R/NF-κB pathway in EGFR-mutant NSCLC

Epithelial-mesenchymal transition (EMT) is clinically associated with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in non-small cell lung cancers (NSCLC). However, the mechanisms promoting EMT in EGFR TKI-resistant NSCLC have not been fully elucidat...

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Detalles Bibliográficos
Autores principales:	Li, Ling, Gu, Xiajing, Yue, Jinnan, Zhao, Qingnan, Lv, Dacheng, Chen, Hongzhuan, Xu, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696177/ https://www.ncbi.nlm.nih.gov/pubmed/29190911 http://dx.doi.org/10.18632/oncotarget.21170

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