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The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma
Despite their critical roles in angiogenesis and host immunosuppression within the tumor microenvironment, the prognostic significance of myeloid-lineage cells expressing CD11b and CX3CR1 in diffuse large B-cell lymphoma (DLBCL) has not been well studied. We prospectively enrolled newly-diagnosed DL...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696181/ https://www.ncbi.nlm.nih.gov/pubmed/29190915 http://dx.doi.org/10.18632/oncotarget.21241 |
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author | Yhim, Ho-Young Kim, Jeong-A Ko, Sun-Hye Park, Youngrok Yim, Eunjung Kim, Hee Sun Kwak, Jae-Yong |
author_facet | Yhim, Ho-Young Kim, Jeong-A Ko, Sun-Hye Park, Youngrok Yim, Eunjung Kim, Hee Sun Kwak, Jae-Yong |
author_sort | Yhim, Ho-Young |
collection | PubMed |
description | Despite their critical roles in angiogenesis and host immunosuppression within the tumor microenvironment, the prognostic significance of myeloid-lineage cells expressing CD11b and CX3CR1 in diffuse large B-cell lymphoma (DLBCL) has not been well studied. We prospectively enrolled newly-diagnosed DLBCL patients at two Korean institutions between May 2011 and Aug 2015. CD11b(+)CX3CR1(+) cells were analyzed by flow cytometry using peripheral blood (PB) and bone marrow (BM) aspirate samples before treatments. Eighty-nine patients (52 males) were enrolled. The median age was 65 years (range, 19–88 years). Thirty-seven patients (42%) were classified as high-intermediate or high risk according to the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI). Patients were categorized into either high or low PB-/BM-CD11b(+)CX3CR1(+) monocyte group according to the cutoffs identified by the receiver-operating-characteristics analysis (PB, 3.68%; BM, 3.45%). The high PB-CD11b(+)CX3CR1(+) monocyte group was significantly associated with high-intermediate and high risk NCCN-IPI group (P = 0.004). With a median follow-up of 27.7 months (range, 1.7-60.4 months), the low PB-CD11b(+)CX3CR1(+) monocyte group showed significantly better overall survival (OS) than the high PB-CD11b(+)CX3CR1(+) monocyte group (3-year, 92.3% vs. 51.2%, respectively; P < 0.001). In contrast, no significant difference was observed between the high and low BM-CD11b(+)CX3CR1(+) monocyte groups. Among patients with high-intermediate to high risk NCCN-IPI, the high PB-CD11b(+)CX3CR1(+) monocyte group showed significantly worse OS than the low PB-CD11b(+)CX3CR1(+) monocyte group (3-year, 29.3% vs. 80.2%, respectively; P = 0.008). Taken together, PB-CD11b(+)CX3CR1(+) monocyte percentage correlates with the NCCN-IPI risk stratification, which enables identification of subgroups with extremely poor clinical outcomes. |
format | Online Article Text |
id | pubmed-5696181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56961812017-11-29 The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma Yhim, Ho-Young Kim, Jeong-A Ko, Sun-Hye Park, Youngrok Yim, Eunjung Kim, Hee Sun Kwak, Jae-Yong Oncotarget Research Paper Despite their critical roles in angiogenesis and host immunosuppression within the tumor microenvironment, the prognostic significance of myeloid-lineage cells expressing CD11b and CX3CR1 in diffuse large B-cell lymphoma (DLBCL) has not been well studied. We prospectively enrolled newly-diagnosed DLBCL patients at two Korean institutions between May 2011 and Aug 2015. CD11b(+)CX3CR1(+) cells were analyzed by flow cytometry using peripheral blood (PB) and bone marrow (BM) aspirate samples before treatments. Eighty-nine patients (52 males) were enrolled. The median age was 65 years (range, 19–88 years). Thirty-seven patients (42%) were classified as high-intermediate or high risk according to the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI). Patients were categorized into either high or low PB-/BM-CD11b(+)CX3CR1(+) monocyte group according to the cutoffs identified by the receiver-operating-characteristics analysis (PB, 3.68%; BM, 3.45%). The high PB-CD11b(+)CX3CR1(+) monocyte group was significantly associated with high-intermediate and high risk NCCN-IPI group (P = 0.004). With a median follow-up of 27.7 months (range, 1.7-60.4 months), the low PB-CD11b(+)CX3CR1(+) monocyte group showed significantly better overall survival (OS) than the high PB-CD11b(+)CX3CR1(+) monocyte group (3-year, 92.3% vs. 51.2%, respectively; P < 0.001). In contrast, no significant difference was observed between the high and low BM-CD11b(+)CX3CR1(+) monocyte groups. Among patients with high-intermediate to high risk NCCN-IPI, the high PB-CD11b(+)CX3CR1(+) monocyte group showed significantly worse OS than the low PB-CD11b(+)CX3CR1(+) monocyte group (3-year, 29.3% vs. 80.2%, respectively; P = 0.008). Taken together, PB-CD11b(+)CX3CR1(+) monocyte percentage correlates with the NCCN-IPI risk stratification, which enables identification of subgroups with extremely poor clinical outcomes. Impact Journals LLC 2017-09-23 /pmc/articles/PMC5696181/ /pubmed/29190915 http://dx.doi.org/10.18632/oncotarget.21241 Text en Copyright: © 2017 Yhim et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Yhim, Ho-Young Kim, Jeong-A Ko, Sun-Hye Park, Youngrok Yim, Eunjung Kim, Hee Sun Kwak, Jae-Yong The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma |
title | The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma |
title_full | The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma |
title_fullStr | The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma |
title_full_unstemmed | The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma |
title_short | The prognostic significance of CD11b(+)CX3CR1(+) monocytes in patients with newly diagnosed diffuse large B-cell lymphoma |
title_sort | prognostic significance of cd11b(+)cx3cr1(+) monocytes in patients with newly diagnosed diffuse large b-cell lymphoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696181/ https://www.ncbi.nlm.nih.gov/pubmed/29190915 http://dx.doi.org/10.18632/oncotarget.21241 |
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