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Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice
Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696209/ https://www.ncbi.nlm.nih.gov/pubmed/29190943 http://dx.doi.org/10.18632/oncotarget.21515 |
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author | Cai, Haobin Wang, Yijie He, Jiayang Cai, Tiantian Wu, Jun Fang, Jiansong Zhang, Rong Guo, Zhouke Guan, Li Zhan, Qinkai Lin, Li Xiao, Yao Pan, Huafeng Wang, Qi |
author_facet | Cai, Haobin Wang, Yijie He, Jiayang Cai, Tiantian Wu, Jun Fang, Jiansong Zhang, Rong Guo, Zhouke Guan, Li Zhan, Qinkai Lin, Li Xiao, Yao Pan, Huafeng Wang, Qi |
author_sort | Cai, Haobin |
collection | PubMed |
description | Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed that BJJS could significantly improve the learning and memory abilities in APP/PS1 mice. BJJS treatment increased the level of insulin degradation enzyme (IDE) and neprilysin (NEP) and decreased the level of β-site app cleaving enzyme 1(BACE1) in the brain of APP/PS1 mice. BJJS-treated APP/PS1 mice appeared to have reductions of Aβ deposition and senile plaques, and showed higher levels of neurotrophic factors in the brain. We also found that BJJS had an inhibitory function on neuroinflammation in APP/PS1 mice. In addition, the synapse structure relevant proteins were elevated in the brain of BJJS-treated APP/PS1 mice. The present results indicated that BJJS could attenuate cognitive impairment via ameliorating the AD-related pathological alterations in APP/PS1 mice. These findings suggest that BJJS may be a potential therapeutic strategy in Alzheimer's disease. |
format | Online Article Text |
id | pubmed-5696209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56962092017-11-29 Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice Cai, Haobin Wang, Yijie He, Jiayang Cai, Tiantian Wu, Jun Fang, Jiansong Zhang, Rong Guo, Zhouke Guan, Li Zhan, Qinkai Lin, Li Xiao, Yao Pan, Huafeng Wang, Qi Oncotarget Research Paper Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed that BJJS could significantly improve the learning and memory abilities in APP/PS1 mice. BJJS treatment increased the level of insulin degradation enzyme (IDE) and neprilysin (NEP) and decreased the level of β-site app cleaving enzyme 1(BACE1) in the brain of APP/PS1 mice. BJJS-treated APP/PS1 mice appeared to have reductions of Aβ deposition and senile plaques, and showed higher levels of neurotrophic factors in the brain. We also found that BJJS had an inhibitory function on neuroinflammation in APP/PS1 mice. In addition, the synapse structure relevant proteins were elevated in the brain of BJJS-treated APP/PS1 mice. The present results indicated that BJJS could attenuate cognitive impairment via ameliorating the AD-related pathological alterations in APP/PS1 mice. These findings suggest that BJJS may be a potential therapeutic strategy in Alzheimer's disease. Impact Journals LLC 2017-10-04 /pmc/articles/PMC5696209/ /pubmed/29190943 http://dx.doi.org/10.18632/oncotarget.21515 Text en Copyright: © 2017 Cai et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Cai, Haobin Wang, Yijie He, Jiayang Cai, Tiantian Wu, Jun Fang, Jiansong Zhang, Rong Guo, Zhouke Guan, Li Zhan, Qinkai Lin, Li Xiao, Yao Pan, Huafeng Wang, Qi Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice |
title | Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice |
title_full | Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice |
title_fullStr | Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice |
title_full_unstemmed | Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice |
title_short | Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice |
title_sort | neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in app/ps1 mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696209/ https://www.ncbi.nlm.nih.gov/pubmed/29190943 http://dx.doi.org/10.18632/oncotarget.21515 |
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