Cargando…

LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling

BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is a long noncoding RNA that was identified as an oncogene in breast cancer. In our research, we found that the expression level of BCAR4 was upregulated in colon cancer tissues compared to paired normal tissues. What's more, higher BCAR4 express...

Descripción completa

Detalles Bibliográficos
Autores principales: Ouyang, Shurui, Zheng, Xinbin, Zhou, Xin, Chen, Zhengquan, Yang, Xuefeng, Xie, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696224/
https://www.ncbi.nlm.nih.gov/pubmed/29190958
http://dx.doi.org/10.18632/oncotarget.21590
_version_ 1783280404604649472
author Ouyang, Shurui
Zheng, Xinbin
Zhou, Xin
Chen, Zhengquan
Yang, Xuefeng
Xie, Ming
author_facet Ouyang, Shurui
Zheng, Xinbin
Zhou, Xin
Chen, Zhengquan
Yang, Xuefeng
Xie, Ming
author_sort Ouyang, Shurui
collection PubMed
description BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is a long noncoding RNA that was identified as an oncogene in breast cancer. In our research, we found that the expression level of BCAR4 was upregulated in colon cancer tissues compared to paired normal tissues. What's more, higher BCAR4 expression was correlated with lower survival rate in patients with colon cancer. Mechanistically, we showed that BCAR4 activated Wnt/β-catenin signaling in colon cancer by protecting β-catenin from degradation. We also showed that BCAR4 overexpression promoted cell proliferation and migration in colon cancer. However, silencing BCAR4 inhibited cell growth and promoted apoptosis. Besides, BCAR4 knockdown decreased tumor growth in vivo. These findings indicate that BCAR4 facilitated colon cancer progression by enhancing cell proliferation and inhibiting apoptosis via BCAR4/β-catenin axis. BCAR4 may be a useful new target for treatment of patients with colon cancer.
format Online
Article
Text
id pubmed-5696224
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-56962242017-11-29 LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling Ouyang, Shurui Zheng, Xinbin Zhou, Xin Chen, Zhengquan Yang, Xuefeng Xie, Ming Oncotarget Research Paper BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is a long noncoding RNA that was identified as an oncogene in breast cancer. In our research, we found that the expression level of BCAR4 was upregulated in colon cancer tissues compared to paired normal tissues. What's more, higher BCAR4 expression was correlated with lower survival rate in patients with colon cancer. Mechanistically, we showed that BCAR4 activated Wnt/β-catenin signaling in colon cancer by protecting β-catenin from degradation. We also showed that BCAR4 overexpression promoted cell proliferation and migration in colon cancer. However, silencing BCAR4 inhibited cell growth and promoted apoptosis. Besides, BCAR4 knockdown decreased tumor growth in vivo. These findings indicate that BCAR4 facilitated colon cancer progression by enhancing cell proliferation and inhibiting apoptosis via BCAR4/β-catenin axis. BCAR4 may be a useful new target for treatment of patients with colon cancer. Impact Journals LLC 2017-10-06 /pmc/articles/PMC5696224/ /pubmed/29190958 http://dx.doi.org/10.18632/oncotarget.21590 Text en Copyright: © 2017 Ouyang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Ouyang, Shurui
Zheng, Xinbin
Zhou, Xin
Chen, Zhengquan
Yang, Xuefeng
Xie, Ming
LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
title LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
title_full LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
title_fullStr LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
title_full_unstemmed LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
title_short LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
title_sort lncrna bcar4 promotes colon cancer progression via activating wnt/β-catenin signaling
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696224/
https://www.ncbi.nlm.nih.gov/pubmed/29190958
http://dx.doi.org/10.18632/oncotarget.21590
work_keys_str_mv AT ouyangshurui lncrnabcar4promotescoloncancerprogressionviaactivatingwntbcateninsignaling
AT zhengxinbin lncrnabcar4promotescoloncancerprogressionviaactivatingwntbcateninsignaling
AT zhouxin lncrnabcar4promotescoloncancerprogressionviaactivatingwntbcateninsignaling
AT chenzhengquan lncrnabcar4promotescoloncancerprogressionviaactivatingwntbcateninsignaling
AT yangxuefeng lncrnabcar4promotescoloncancerprogressionviaactivatingwntbcateninsignaling
AT xieming lncrnabcar4promotescoloncancerprogressionviaactivatingwntbcateninsignaling