Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genome-wide screen for CT genes with the identification of 745...

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Detalles Bibliográficos
Autores principales: da Silva, Vandeclecio Lira, Fonseca, André Faustino, Fonseca, Marbella, da Silva, Thayna Emilia, Coelho, Ana Carolina, Kroll, José Eduardo, de Souza, Jorge Estefano Santana, Stransky, Beatriz, de Souza, Gustavo Antonio, de Souza, Sandro José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696236/
https://www.ncbi.nlm.nih.gov/pubmed/29190970
http://dx.doi.org/10.18632/oncotarget.21715
Descripción
Sumario:Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genome-wide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma.

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