An approach to suppress the evolution of resistance in BRAF(V600E)-mutant cancer

The principles governing evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of BRAF amplification (BRAF(amp)) in patient-derived tumor xenografts (PDX) treated with a direct ERK inhibitor, alone or in combination with other pathway in...

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Detalles Bibliográficos
Autores principales: Xue, Yaohua, Martelotto, Luciano, Baslan, Timour, Vides, Alberto, Solomon, Martha, Mai, Trang Thi, Chaudhary, Neelam, Riely, Greg J., Li, Bob T., Scott, Kerry, Cechhi, Fabiola, Stierner, Ulrika, Chadalavada, Kalyani, de Stanchina, Elisa, Schwartz, Sarit, Hembrough, Todd, Nanjangud, Gouri, Berger, Michael F., Nilsson, Jonas, Lowe, Scott, Reis-Filho, Jorge S., Rosen, Neal, Lito, Piro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696266/
https://www.ncbi.nlm.nih.gov/pubmed/28714990
http://dx.doi.org/10.1038/nm.4369

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