NOTCH1 is a mechanosensor in adult arteries

Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integrity, cell elongation, and suppression of proliferat...

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Detalles Bibliográficos
Autores principales: Mack, Julia J., Mosqueiro, Thiago S., Archer, Brian J., Jones, William M., Sunshine, Hannah, Faas, Guido C., Briot, Anais, Aragón, Raquel L., Su, Trent, Romay, Milagros C., McDonald, Austin I., Kuo, Cheng-Hsiang, Lizama, Carlos O., Lane, Timothy F., Zovein, Ann C., Fang, Yun, Tarling, Elizabeth J., de Aguiar Vallim, Thomas Q., Navab, Mohamad, Fogelman, Alan M., Bouchard, Louis S., Iruela-Arispe, M. Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696341/
https://www.ncbi.nlm.nih.gov/pubmed/29158473
http://dx.doi.org/10.1038/s41467-017-01741-8

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