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Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke

Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susce...

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Detalles Bibliográficos
Autores principales: Giraud, Antoine, Guiraut, Clémence, Chevin, Mathilde, Chabrier, Stéphane, Sébire, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696351/
https://www.ncbi.nlm.nih.gov/pubmed/29201015
http://dx.doi.org/10.3389/fneur.2017.00612
Descripción
Sumario:Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research priority in NAIS is to further characterize the nature and spatiotemporal features of the inflammatory processes involved in multiple levels of the pathophysiology of NAIS, to adequately design randomized control trials using targeted anti-inflammatory vasculo- and neuroprotective agents.