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Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke
Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696351/ https://www.ncbi.nlm.nih.gov/pubmed/29201015 http://dx.doi.org/10.3389/fneur.2017.00612 |
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author | Giraud, Antoine Guiraut, Clémence Chevin, Mathilde Chabrier, Stéphane Sébire, Guillaume |
author_facet | Giraud, Antoine Guiraut, Clémence Chevin, Mathilde Chabrier, Stéphane Sébire, Guillaume |
author_sort | Giraud, Antoine |
collection | PubMed |
description | Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research priority in NAIS is to further characterize the nature and spatiotemporal features of the inflammatory processes involved in multiple levels of the pathophysiology of NAIS, to adequately design randomized control trials using targeted anti-inflammatory vasculo- and neuroprotective agents. |
format | Online Article Text |
id | pubmed-5696351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56963512017-11-30 Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke Giraud, Antoine Guiraut, Clémence Chevin, Mathilde Chabrier, Stéphane Sébire, Guillaume Front Neurol Neuroscience Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research priority in NAIS is to further characterize the nature and spatiotemporal features of the inflammatory processes involved in multiple levels of the pathophysiology of NAIS, to adequately design randomized control trials using targeted anti-inflammatory vasculo- and neuroprotective agents. Frontiers Media S.A. 2017-11-16 /pmc/articles/PMC5696351/ /pubmed/29201015 http://dx.doi.org/10.3389/fneur.2017.00612 Text en Copyright © 2017 Giraud, Guiraut, Chevin, Chabrier and Sébire. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Giraud, Antoine Guiraut, Clémence Chevin, Mathilde Chabrier, Stéphane Sébire, Guillaume Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke |
title | Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke |
title_full | Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke |
title_fullStr | Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke |
title_full_unstemmed | Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke |
title_short | Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke |
title_sort | role of perinatal inflammation in neonatal arterial ischemic stroke |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696351/ https://www.ncbi.nlm.nih.gov/pubmed/29201015 http://dx.doi.org/10.3389/fneur.2017.00612 |
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