Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

Fusidane-type antibiotics represented by helvolic acid, fusidic acid and cephalosporin P(1) are a class of bacteriostatic agents, which have drawn renewed attention because they have no cross-resistance to commonly used antibiotics. However, their biosynthesis is poorly understood. Here, we perform...

Descripción completa

Detalles Bibliográficos
Autores principales: Lv, Jian-Ming, Hu, Dan, Gao, Hao, Kushiro, Tetsuo, Awakawa, Takayoshi, Chen, Guo-Dong, Wang, Chuan-Xi, Abe, Ikuro, Yao, Xin-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696383/
https://www.ncbi.nlm.nih.gov/pubmed/29158519
http://dx.doi.org/10.1038/s41467-017-01813-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696383/
https://www.ncbi.nlm.nih.gov/pubmed/29158519
http://dx.doi.org/10.1038/s41467-017-01813-9

Ejemplares similares