A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum

CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantib...

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Autores principales: van de Vosse, Esther, van Wengen, Annelies, van der Meide, Wendy F., Visser, Leo G., van Dissel, Jaap T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696445/
https://www.ncbi.nlm.nih.gov/pubmed/28822097
http://dx.doi.org/10.1007/s15010-017-1060-x
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author van de Vosse, Esther
van Wengen, Annelies
van der Meide, Wendy F.
Visser, Leo G.
van Dissel, Jaap T.
author_facet van de Vosse, Esther
van Wengen, Annelies
van der Meide, Wendy F.
Visser, Leo G.
van Dissel, Jaap T.
author_sort van de Vosse, Esther
collection PubMed
description CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies.
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spelling pubmed-56964452017-11-30 A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum van de Vosse, Esther van Wengen, Annelies van der Meide, Wendy F. Visser, Leo G. van Dissel, Jaap T. Infection Case Report CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies. Springer Berlin Heidelberg 2017-08-18 2017 /pmc/articles/PMC5696445/ /pubmed/28822097 http://dx.doi.org/10.1007/s15010-017-1060-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
van de Vosse, Esther
van Wengen, Annelies
van der Meide, Wendy F.
Visser, Leo G.
van Dissel, Jaap T.
A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
title A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
title_full A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
title_fullStr A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
title_full_unstemmed A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
title_short A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
title_sort 38-year-old woman with necrotising cervical lymphadenitis due to histoplasma capsulatum
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696445/
https://www.ncbi.nlm.nih.gov/pubmed/28822097
http://dx.doi.org/10.1007/s15010-017-1060-x
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