Calcium binding and voltage gating in Cx46 hemichannels

The opening of connexin (Cx) hemichannels in the membrane is tightly regulated by calcium (Ca(2+)) and membrane voltage. Electrophysiological and atomic force microscopy experiments indicate that Ca(2+) stabilizes the hemichannel closed state. However, structural data show that Ca(2+) binding induce...

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Detalles Bibliográficos
Autores principales: Pinto, Bernardo I., Pupo, Amaury, García, Isaac E., Mena-Ulecia, Karel, Martínez, Agustín D., Latorre, Ramón, Gonzalez, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696461/
https://www.ncbi.nlm.nih.gov/pubmed/29158540
http://dx.doi.org/10.1038/s41598-017-15975-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696461/
https://www.ncbi.nlm.nih.gov/pubmed/29158540
http://dx.doi.org/10.1038/s41598-017-15975-5

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