Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture

Decorin (DCN) is a small-leucine rich proteoglycan that mediates collagen fibrillogenesis, organization, and tensile strength. Adventitial DCN is reduced in abdominal aortic aneurysm (AAA) resulting in vessel wall instability thereby predisposing the vessel to rupture. Recombinant DCN fusion protein...

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Detalles Bibliográficos
Autores principales: Shen, Yue, Russo, Valerio, Zeglinski, Matthew R., Sellers, Stephanie L., Wu, Zhengguo, Oram, Cameron, Santacruz, Stephanie, Merkulova, Yulia, Turner, Christopher, Tauh, Keerit, Zhao, Hongyan, Bozin, Tatjana, Bohunek, Lubos, Zeng, Haishan, Seidman, Michael A., Bleackley, R. Chris, McManus, Bruce M., Ruoslahti, Erkki, Järvinen, Tero A. H., Granville, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696466/
https://www.ncbi.nlm.nih.gov/pubmed/29158532
http://dx.doi.org/10.1038/s41598-017-16194-8

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