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Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes

Drug-induced off-target cardiotoxicity, particularly following anti-cancer therapy, is a major concern in new drug discovery and development. To ensure patient safety and efficient pharmaceutical drug development, there is an urgent need to develop more predictive cell model systems and distinct tox...

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Detalles Bibliográficos
Autores principales:	Chaudhari, Umesh, Ellis, James K., Wagh, Vilas, Nemade, Harshal, Hescheler, Jürgen, Keun, Hector C., Sachinidis, Agapios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Vienna 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696498/ https://www.ncbi.nlm.nih.gov/pubmed/28421296 http://dx.doi.org/10.1007/s00726-017-2419-0

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