Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells

Sirolimus (rapamycin) is an immunosuppressive drug used in transplantation. One of its major side effects is the increased risk of diabetes mellitus; however, the exact mechanisms underlying such association have not been elucidated. Here we show that sirolimus impairs glucose-stimulated insulin sec...

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Detalles Bibliográficos
Autores principales: Lombardi, Angela, Gambardella, Jessica, Du, Xue-Liang, Sorriento, Daniela, Mauro, Maurizio, Iaccarino, Guido, Trimarco, Bruno, Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696524/
https://www.ncbi.nlm.nih.gov/pubmed/29158477
http://dx.doi.org/10.1038/s41598-017-15283-y

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