Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A

Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While a...

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Detalles Bibliográficos
Autores principales: Beske, Phillip H., Hoffman, Katie M., Machamer, James B., Eisen, Margaret R., McNutt, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696531/
https://www.ncbi.nlm.nih.gov/pubmed/29158500
http://dx.doi.org/10.1038/s41598-017-16064-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696531/
https://www.ncbi.nlm.nih.gov/pubmed/29158500
http://dx.doi.org/10.1038/s41598-017-16064-3

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