The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs

Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential...

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Detalles Bibliográficos
Autores principales: Metcalf Pate, Kelly A., Blankson, Joel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697021/
https://www.ncbi.nlm.nih.gov/pubmed/29157283
http://dx.doi.org/10.1186/s12977-017-0376-z
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author Metcalf Pate, Kelly A.
Blankson, Joel N.
author_facet Metcalf Pate, Kelly A.
Blankson, Joel N.
author_sort Metcalf Pate, Kelly A.
collection PubMed
description Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential to be more sensitive than traditional in vitro quantitative viral outgrowth assays. In this article we describe these assays and review several studies that have used them to measure the latent reservoir.
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spelling pubmed-56970212017-12-01 The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs Metcalf Pate, Kelly A. Blankson, Joel N. Retrovirology Review Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential to be more sensitive than traditional in vitro quantitative viral outgrowth assays. In this article we describe these assays and review several studies that have used them to measure the latent reservoir. BioMed Central 2017-11-21 /pmc/articles/PMC5697021/ /pubmed/29157283 http://dx.doi.org/10.1186/s12977-017-0376-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Metcalf Pate, Kelly A.
Blankson, Joel N.
The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
title The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
title_full The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
title_fullStr The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
title_full_unstemmed The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
title_short The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
title_sort mouse viral outgrowth assay: avatars for the detection of hiv-1 reservoirs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697021/
https://www.ncbi.nlm.nih.gov/pubmed/29157283
http://dx.doi.org/10.1186/s12977-017-0376-z
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