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Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma

BACKGROUND: Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought to determine the therapeutic efficiency of PTC-209, a potent and selective Bmi1...

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Detalles Bibliográficos
Autores principales:	Wang, Qiong, Li, Zhongwu, Wu, Yaping, Huang, Rong, Zhu, Yumin, Zhang, Wei, Wang, Yanling, Cheng, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697105/ https://www.ncbi.nlm.nih.gov/pubmed/29200967 http://dx.doi.org/10.1186/s12935-017-0481-z

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