The effects of progesterones on blood lipids in hormone replacement therapy

The safety of progestogens as a class has drawn much attention after the publication of data from the Women’s Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on the chemical structure, pharmacokinetics, receptor affinity and potency of action, progestoge...

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Detalles Bibliográficos
Autores principales: Jiang, Yifan, Tian, Weijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697110/
https://www.ncbi.nlm.nih.gov/pubmed/29157280
http://dx.doi.org/10.1186/s12944-017-0612-5
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author Jiang, Yifan
Tian, Weijie
author_facet Jiang, Yifan
Tian, Weijie
author_sort Jiang, Yifan
collection PubMed
description The safety of progestogens as a class has drawn much attention after the publication of data from the Women’s Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on the chemical structure, pharmacokinetics, receptor affinity and potency of action, progestogens have a divergent range of properties that may translate to very different clinical effects. The purpose of this review is to describe the role of varied progestogens in hormone replacement therapy (HRT), especially focusing on blood lipids, which are the most important parameters for assessing cardiovascular disease risk.
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spelling pubmed-56971102017-12-01 The effects of progesterones on blood lipids in hormone replacement therapy Jiang, Yifan Tian, Weijie Lipids Health Dis Review The safety of progestogens as a class has drawn much attention after the publication of data from the Women’s Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on the chemical structure, pharmacokinetics, receptor affinity and potency of action, progestogens have a divergent range of properties that may translate to very different clinical effects. The purpose of this review is to describe the role of varied progestogens in hormone replacement therapy (HRT), especially focusing on blood lipids, which are the most important parameters for assessing cardiovascular disease risk. BioMed Central 2017-11-21 /pmc/articles/PMC5697110/ /pubmed/29157280 http://dx.doi.org/10.1186/s12944-017-0612-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jiang, Yifan
Tian, Weijie
The effects of progesterones on blood lipids in hormone replacement therapy
title The effects of progesterones on blood lipids in hormone replacement therapy
title_full The effects of progesterones on blood lipids in hormone replacement therapy
title_fullStr The effects of progesterones on blood lipids in hormone replacement therapy
title_full_unstemmed The effects of progesterones on blood lipids in hormone replacement therapy
title_short The effects of progesterones on blood lipids in hormone replacement therapy
title_sort effects of progesterones on blood lipids in hormone replacement therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697110/
https://www.ncbi.nlm.nih.gov/pubmed/29157280
http://dx.doi.org/10.1186/s12944-017-0612-5
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