Cargando…
Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
BACKGROUND: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. OBJECTIVE: Cone parameters and retinal microvasculature were analyzed...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697118/ https://www.ncbi.nlm.nih.gov/pubmed/29238728 http://dx.doi.org/10.1155/2017/4174292 |
_version_ | 1783280548162043904 |
---|---|
author | Zaleska-Żmijewska, Anna Piątkiewicz, Paweł Śmigielska, Barbara Sokołowska-Oracz, Anna Wawrzyniak, Zbigniew M. Romaniuk, Dorota Szaflik, Jerzy Szaflik, Jacek P. |
author_facet | Zaleska-Żmijewska, Anna Piątkiewicz, Paweł Śmigielska, Barbara Sokołowska-Oracz, Anna Wawrzyniak, Zbigniew M. Romaniuk, Dorota Szaflik, Jerzy Szaflik, Jacek P. |
author_sort | Zaleska-Żmijewska, Anna |
collection | PubMed |
description | BACKGROUND: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. OBJECTIVE: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall. RESULTS: DM in the prediabetic group was not significantly lower than that in the control group (18,935 ± 1713 cells/mm(2) and 19,900 ± 2375 cells/mm(2), respectively; p = 0.0928). The LD and WLR means differed significantly between the prediabetic and the control groups (LD 94.3 ± 10.9 versus 101.2 ± 15, p = 0.022; WLR 0.29 ± 0.05 versus 0.22 ± 0.03, p < 0.05). A multivariate regression analysis showed that the WLR was significantly correlated with BMI and total cholesterol. CONCLUSIONS: Abnormalities found in rtx1 examinations indicated early signs of arteriolar dysfunction, prior to impaired glucose tolerance progressing to diabetes. The rtx1 retinal image analysis offers noninvasive measurement of early changes in the vasculature that routine clinical examination cannot detect. |
format | Online Article Text |
id | pubmed-5697118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56971182017-12-13 Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study Zaleska-Żmijewska, Anna Piątkiewicz, Paweł Śmigielska, Barbara Sokołowska-Oracz, Anna Wawrzyniak, Zbigniew M. Romaniuk, Dorota Szaflik, Jerzy Szaflik, Jacek P. J Diabetes Res Research Article BACKGROUND: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. OBJECTIVE: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall. RESULTS: DM in the prediabetic group was not significantly lower than that in the control group (18,935 ± 1713 cells/mm(2) and 19,900 ± 2375 cells/mm(2), respectively; p = 0.0928). The LD and WLR means differed significantly between the prediabetic and the control groups (LD 94.3 ± 10.9 versus 101.2 ± 15, p = 0.022; WLR 0.29 ± 0.05 versus 0.22 ± 0.03, p < 0.05). A multivariate regression analysis showed that the WLR was significantly correlated with BMI and total cholesterol. CONCLUSIONS: Abnormalities found in rtx1 examinations indicated early signs of arteriolar dysfunction, prior to impaired glucose tolerance progressing to diabetes. The rtx1 retinal image analysis offers noninvasive measurement of early changes in the vasculature that routine clinical examination cannot detect. Hindawi 2017 2017-11-07 /pmc/articles/PMC5697118/ /pubmed/29238728 http://dx.doi.org/10.1155/2017/4174292 Text en Copyright © 2017 Anna Zaleska-Żmijewska et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zaleska-Żmijewska, Anna Piątkiewicz, Paweł Śmigielska, Barbara Sokołowska-Oracz, Anna Wawrzyniak, Zbigniew M. Romaniuk, Dorota Szaflik, Jerzy Szaflik, Jacek P. Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study |
title | Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study |
title_full | Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study |
title_fullStr | Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study |
title_full_unstemmed | Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study |
title_short | Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study |
title_sort | retinal photoreceptors and microvascular changes in prediabetes measured with adaptive optics (rtx1™): a case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697118/ https://www.ncbi.nlm.nih.gov/pubmed/29238728 http://dx.doi.org/10.1155/2017/4174292 |
work_keys_str_mv | AT zaleskazmijewskaanna retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT piatkiewiczpaweł retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT smigielskabarbara retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT sokołowskaoraczanna retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT wawrzyniakzbigniewm retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT romaniukdorota retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT szaflikjerzy retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy AT szaflikjacekp retinalphotoreceptorsandmicrovascularchangesinprediabetesmeasuredwithadaptiveopticsrtx1acasecontrolstudy |