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Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study

BACKGROUND: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. OBJECTIVE: Cone parameters and retinal microvasculature were analyzed...

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Autores principales: Zaleska-Żmijewska, Anna, Piątkiewicz, Paweł, Śmigielska, Barbara, Sokołowska-Oracz, Anna, Wawrzyniak, Zbigniew M., Romaniuk, Dorota, Szaflik, Jerzy, Szaflik, Jacek P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697118/
https://www.ncbi.nlm.nih.gov/pubmed/29238728
http://dx.doi.org/10.1155/2017/4174292
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author Zaleska-Żmijewska, Anna
Piątkiewicz, Paweł
Śmigielska, Barbara
Sokołowska-Oracz, Anna
Wawrzyniak, Zbigniew M.
Romaniuk, Dorota
Szaflik, Jerzy
Szaflik, Jacek P.
author_facet Zaleska-Żmijewska, Anna
Piątkiewicz, Paweł
Śmigielska, Barbara
Sokołowska-Oracz, Anna
Wawrzyniak, Zbigniew M.
Romaniuk, Dorota
Szaflik, Jerzy
Szaflik, Jacek P.
author_sort Zaleska-Żmijewska, Anna
collection PubMed
description BACKGROUND: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. OBJECTIVE: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall. RESULTS: DM in the prediabetic group was not significantly lower than that in the control group (18,935 ± 1713 cells/mm(2) and 19,900 ± 2375 cells/mm(2), respectively; p = 0.0928). The LD and WLR means differed significantly between the prediabetic and the control groups (LD 94.3 ± 10.9 versus 101.2 ± 15, p = 0.022; WLR 0.29 ± 0.05 versus 0.22 ± 0.03, p < 0.05). A multivariate regression analysis showed that the WLR was significantly correlated with BMI and total cholesterol. CONCLUSIONS: Abnormalities found in rtx1 examinations indicated early signs of arteriolar dysfunction, prior to impaired glucose tolerance progressing to diabetes. The rtx1 retinal image analysis offers noninvasive measurement of early changes in the vasculature that routine clinical examination cannot detect.
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spelling pubmed-56971182017-12-13 Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study Zaleska-Żmijewska, Anna Piątkiewicz, Paweł Śmigielska, Barbara Sokołowska-Oracz, Anna Wawrzyniak, Zbigniew M. Romaniuk, Dorota Szaflik, Jerzy Szaflik, Jacek P. J Diabetes Res Research Article BACKGROUND: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. OBJECTIVE: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall. RESULTS: DM in the prediabetic group was not significantly lower than that in the control group (18,935 ± 1713 cells/mm(2) and 19,900 ± 2375 cells/mm(2), respectively; p = 0.0928). The LD and WLR means differed significantly between the prediabetic and the control groups (LD 94.3 ± 10.9 versus 101.2 ± 15, p = 0.022; WLR 0.29 ± 0.05 versus 0.22 ± 0.03, p < 0.05). A multivariate regression analysis showed that the WLR was significantly correlated with BMI and total cholesterol. CONCLUSIONS: Abnormalities found in rtx1 examinations indicated early signs of arteriolar dysfunction, prior to impaired glucose tolerance progressing to diabetes. The rtx1 retinal image analysis offers noninvasive measurement of early changes in the vasculature that routine clinical examination cannot detect. Hindawi 2017 2017-11-07 /pmc/articles/PMC5697118/ /pubmed/29238728 http://dx.doi.org/10.1155/2017/4174292 Text en Copyright © 2017 Anna Zaleska-Żmijewska et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zaleska-Żmijewska, Anna
Piątkiewicz, Paweł
Śmigielska, Barbara
Sokołowska-Oracz, Anna
Wawrzyniak, Zbigniew M.
Romaniuk, Dorota
Szaflik, Jerzy
Szaflik, Jacek P.
Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
title Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
title_full Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
title_fullStr Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
title_full_unstemmed Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
title_short Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
title_sort retinal photoreceptors and microvascular changes in prediabetes measured with adaptive optics (rtx1™): a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697118/
https://www.ncbi.nlm.nih.gov/pubmed/29238728
http://dx.doi.org/10.1155/2017/4174292
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